{"id":28343,"date":"2026-07-02T05:16:18","date_gmt":"2026-07-02T09:16:18","guid":{"rendered":"https:\/\/www.celfull.com\/estudios-relacionados-con-el-nmn"},"modified":"2026-08-24T02:43:05","modified_gmt":"2026-08-24T06:43:05","slug":"estudios-relacionados-con-el-nmn","status":"publish","type":"page","link":"https:\/\/www.celfull.com\/es\/estudios-relacionados-con-el-nmn","title":{"rendered":"Estudios relacionados con el NMN"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"28343\" class=\"elementor elementor-28343 elementor-26885\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-210c465 e-flex e-con-boxed e-con e-parent\" data-id=\"210c465\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-db5fa0f elementor-widget elementor-widget-shortcode\" data-id=\"db5fa0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-864d148 e-flex e-con-boxed e-con e-parent\" data-id=\"864d148\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6cb8129 elementor-widget elementor-widget-heading\" data-id=\"6cb8129\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Efecto del NMN y del ejercicio en personas de mediana y avanzada edad<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ec3286d e-flex e-con-boxed e-con e-parent\" data-id=\"ec3286d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c18b403 e-con-full e-flex e-con e-child\" data-id=\"c18b403\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-14e7418 elementor-widget elementor-widget-text-editor\" data-id=\"14e7418\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Resultados:<\/h3><div class=\"ytable\"><div class=\"ytable-cell txt\"><p>En un ensayo cl\u00ednico doble ciego y controlado con placebo se evaluaron los efectos del NMN y del ejercicio aer\u00f3bico. Los resultados mostraron que la suplementaci\u00f3n oral con NMN \u2014500 o 1000 mg al d\u00eda durante 30 d\u00edas\u2014 aument\u00f3 significativamente los niveles de NAD+ en sangre total de manera dependiente de la dosis. El ejercicio aer\u00f3bico produjo un aumento adicional de los niveles de NAD+, tanto en el grupo de control como en el grupo que recibi\u00f3 NMN. <\/p><p>En el grupo que recibi\u00f3 1000 mg diarios de NMN se identificaron algunos participantes que no respondieron a la suplementaci\u00f3n. Posteriormente, se realiz\u00f3 una secuenciaci\u00f3n masiva de ARN de las c\u00e9lulas mononucleares de sangre perif\u00e9rica (PBMC) de cuatro participantes, incluidos respondedores y no respondedores, y se analizaron los niveles de expresi\u00f3n de genes relacionados con el metabolismo del NAD+.<br \/>Los respondedores presentaron una mayor expresi\u00f3n de enzimas implicadas en la s\u00edntesis de NAD+, como IDO2, NAPRT, NMNAT2 y NAMPT, as\u00ed como del transportador de nucle\u00f3sidos SLC29A3. En cambio, los participantes que no respondieron presentaron una mayor expresi\u00f3n de enzimas consumidoras de NAD+, como SIRT4, PARP14, CD38 y PARP2.  <\/p><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dc449dc e-con-full e-flex e-con e-child\" data-id=\"dc449dc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-604dc3e elementor-widget elementor-widget-image\" data-id=\"604dc3e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"480\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141501D2.jpg\" class=\"attachment-large size-large wp-image-28388\" alt=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141501D2.jpg 800w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141501D2-300x180.jpg 300w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141501D2-768x461.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a71cf8b e-flex e-con-boxed e-con e-parent\" data-id=\"a71cf8b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-6294af7 e-con-full e-flex e-con e-child\" data-id=\"6294af7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d9147d2 elementor-widget elementor-widget-image\" data-id=\"d9147d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"760\" height=\"280\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img1.png\" class=\"attachment-large size-large wp-image-28344\" alt=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img1.png 760w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img1-300x111.png 300w\" sizes=\"(max-width: 760px) 100vw, 760px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-be21761 e-con-full e-flex e-con e-child\" data-id=\"be21761\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c34e44 elementor-widget elementor-widget-text-editor\" data-id=\"8c34e44\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dise\u00f1o del estudio para evaluar los efectos de la suplementaci\u00f3n oral con NMN. La suplementaci\u00f3n diaria con 500 mg de NMN (n = 19) y 1000 mg de NMN (n = 22) durante un mes aument\u00f3 significativamente la concentraci\u00f3n de NAD+ en sangre venosa en comparaci\u00f3n con el grupo de placebo (n = 25).<br \/>Las barras de error representan la desviaci\u00f3n est\u00e1ndar (DE) de cada grupo. La significaci\u00f3n estad\u00edstica se determin\u00f3 mediante un ANOVA de una v\u00eda: *p &lt; 0,05; **p &lt; 0,01; ***p &lt; 0,001; ****p &lt; 0,0001.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9f364e7 e-flex e-con-boxed e-con e-parent\" data-id=\"9f364e7\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c10da65 e-con-full e-flex e-con e-child\" data-id=\"c10da65\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f097182 elementor-widget elementor-widget-text-editor\" data-id=\"f097182\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dise\u00f1o del estudio para evaluar los efectos de la suplementaci\u00f3n oral con NMN combinada con un nivel moderado de ejercicio. Se compararon los efectos de la suplementaci\u00f3n oral con NMN (n = 20) y del ejercicio aer\u00f3bico por s\u00ed solo (n = 21) sobre la concentraci\u00f3n de NAD+ en sangre venosa.<br \/>Las barras de error representan la desviaci\u00f3n est\u00e1ndar (DE) de cada grupo. La significaci\u00f3n estad\u00edstica se determin\u00f3 mediante la prueba t: *p &lt; 0,05; **p &lt; 0,01; ***p &lt; 0,001; ****p &lt; 0,0001.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1b7e762 e-con-full e-flex e-con e-child\" data-id=\"1b7e762\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b759be1 elementor-widget elementor-widget-image\" data-id=\"b759be1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"792\" height=\"305\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img2.png\" class=\"attachment-large size-large wp-image-28345\" alt=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img2.png 792w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img2-300x116.png 300w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img2-768x296.png 768w\" sizes=\"(max-width: 792px) 100vw, 792px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bd646f6 e-flex e-con-boxed e-con e-parent\" data-id=\"bd646f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2b5ee68 elementor-widget elementor-widget-text-editor\" data-id=\"2b5ee68\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Niveles relativos de expresi\u00f3n de genes relacionados con el metabolismo del NAD+ en participantes que respondieron y que no respondieron a la suplementaci\u00f3n con NMN.<br \/>(a) Niveles de NAD+ en sangre total medidos en respondedores y no respondedores despu\u00e9s de 30 d\u00edas de suplementaci\u00f3n con 1000 mg diarios de NMN.<br \/>(b) El perfil de expresi\u00f3n de los genes relacionados con el metabolismo del NAD+ se obtuvo mediante la secuenciaci\u00f3n de PBMC aisladas de sangre venosa al finalizar el estudio cl\u00ednico. El an\u00e1lisis incluy\u00f3 a cuatro participantes clasificados como respondedores o no respondedores seg\u00fan los niveles de NAD+ medidos.<br \/>Las barras de error representan la desviaci\u00f3n est\u00e1ndar (DE). La significaci\u00f3n estad\u00edstica de (a) se calcul\u00f3 mediante la prueba t: ****p &lt; 0,0001.    <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Efecto del NMN y del ejercicio en personas de mediana y avanzada edad Resultados: En un ensayo cl\u00ednico doble ciego y controlado con placebo se evaluaron los efectos del NMN y del ejercicio aer\u00f3bico. Los resultados mostraron que la suplementaci\u00f3n oral con NMN \u2014500 o 1000 mg al d\u00eda durante 30 d\u00edas\u2014 aument\u00f3 significativamente los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_angie_page":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-28343","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.celfull.com\/es\/wp-json\/wp\/v2\/pages\/28343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.celfull.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.celfull.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.celfull.com\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.celfull.com\/es\/wp-json\/wp\/v2\/comments?post=28343"}],"version-history":[{"count":2,"href":"https:\/\/www.celfull.com\/es\/wp-json\/wp\/v2\/pages\/28343\/revisions"}],"predecessor-version":[{"id":28821,"href":"https:\/\/www.celfull.com\/es\/wp-json\/wp\/v2\/pages\/28343\/revisions\/28821"}],"wp:attachment":[{"href":"https:\/\/www.celfull.com\/es\/wp-json\/wp\/v2\/media?parent=28343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}