{"id":28575,"date":"2026-07-02T05:16:18","date_gmt":"2026-07-02T09:16:18","guid":{"rendered":"https:\/\/www.celfull.com\/etudes-cliniques-sur-le-nmn"},"modified":"2026-08-26T01:49:09","modified_gmt":"2026-08-26T05:49:09","slug":"etudes-cliniques-sur-le-nmn","status":"publish","type":"page","link":"https:\/\/www.celfull.com\/fr\/etudes-cliniques-sur-le-nmn","title":{"rendered":"\u00c9tudes cliniques sur le NMN"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"28575\" class=\"elementor elementor-28575 elementor-26885\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-210c465 e-flex e-con-boxed e-con e-parent\" data-id=\"210c465\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-db5fa0f elementor-widget elementor-widget-shortcode\" data-id=\"db5fa0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-864d148 e-flex e-con-boxed e-con e-parent\" data-id=\"864d148\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6cb8129 elementor-widget elementor-widget-heading\" data-id=\"6cb8129\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Effets du NMN et de l\u2019exercice physique chez les personnes d\u2019\u00e2ge moyen et les personnes \u00e2g\u00e9es<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ec3286d e-flex e-con-boxed e-con e-parent\" data-id=\"ec3286d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c18b403 e-con-full e-flex e-con e-child\" data-id=\"c18b403\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-14e7418 elementor-widget elementor-widget-text-editor\" data-id=\"14e7418\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>R\u00e9sultats :<\/h3><div class=\"ytable\"><div class=\"ytable-cell txt\"><p>Dans le cadre d\u2019un essai clinique contr\u00f4l\u00e9 par placebo et men\u00e9 en double aveugle afin d\u2019\u00e9valuer les effets du NMN et de l\u2019exercice a\u00e9robie, nous avons d\u00e9montr\u00e9 qu\u2019une suppl\u00e9mentation orale en NMN (500 mg\/jour ou 1 000 mg\/jour) pendant 30 jours pouvait augmenter significativement les taux de NAD+ dans le sang total, de mani\u00e8re dose-d\u00e9pendante. L\u2019exercice a\u00e9robie peut en outre accro\u00eetre les taux de NAD+ aussi bien dans le groupe t\u00e9moin que dans le groupe trait\u00e9 par NMN. <\/p><p>Dans le groupe trait\u00e9 par 1 000 mg\/jour de NMN, nous avons constat\u00e9 que certains participants ne r\u00e9pondaient pas \u00e0 l\u2019administration de NMN. Nous avons ensuite r\u00e9alis\u00e9 un s\u00e9quen\u00e7age massif de l\u2019ARN des cellules mononucl\u00e9\u00e9es du sang p\u00e9riph\u00e9rique (PBMC) provenant de quatre sujets r\u00e9pondeurs et de quatre sujets non-r\u00e9pondeurs du groupe recevant 1 000 mg\/jour, puis \u00e9tabli le profil d\u2019expression des g\u00e8nes impliqu\u00e9s dans le m\u00e9tabolisme du NAD+. Les r\u00e9pondeurs pr\u00e9sentaient une expression plus \u00e9lev\u00e9e des enzymes participant \u00e0 la synth\u00e8se du NAD+, notamment IDO2, NAPRT, NMNAT2 et NAMPT, ainsi que du transporteur de nucl\u00e9osides SLC29A3. En revanche, les non-r\u00e9pondeurs pr\u00e9sentaient une expression plus \u00e9lev\u00e9e des enzymes consommant le NAD+, telles que SIRT4, PARP14, CD38 et PARP2.  <\/p><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dc449dc e-con-full e-flex e-con e-child\" data-id=\"dc449dc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-604dc3e elementor-widget elementor-widget-image\" data-id=\"604dc3e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"480\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141501D2.jpg\" class=\"attachment-large size-large wp-image-28563\" alt=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141501D2.jpg 800w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141501D2-300x180.jpg 300w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141501D2-768x461.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a71cf8b e-flex e-con-boxed e-con e-parent\" data-id=\"a71cf8b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-6294af7 e-con-full e-flex e-con e-child\" data-id=\"6294af7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d9147d2 elementor-widget elementor-widget-image\" data-id=\"d9147d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"760\" height=\"280\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img1.png\" class=\"attachment-large size-large wp-image-28576\" alt=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img1.png 760w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img1-300x111.png 300w\" sizes=\"(max-width: 760px) 100vw, 760px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-be21761 e-con-full e-flex e-con e-child\" data-id=\"be21761\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c34e44 elementor-widget elementor-widget-text-editor\" data-id=\"8c34e44\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Plan de l\u2019\u00e9tude visant \u00e0 \u00e9valuer les effets d\u2019une suppl\u00e9mentation orale en NMN. Une suppl\u00e9mentation quotidienne de 500 mg (n = 19) ou de 1 000 mg de NMN (n = 22) pendant un mois a significativement augment\u00e9 la concentration veineuse en NAD+ par rapport au groupe placebo (n = 25). Les barres d\u2019erreur repr\u00e9sentent l\u2019\u00e9cart-type (ET) de chaque groupe. La significativit\u00e9 a \u00e9t\u00e9 d\u00e9termin\u00e9e par une analyse de variance \u00e0 un facteur (ANOVA) : * p &lt; 0,05 ; ** p &lt; 0,01 ; *** p &lt; 0,001 ; **** p &lt; 0,0001.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9f364e7 e-flex e-con-boxed e-con e-parent\" data-id=\"9f364e7\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c10da65 e-con-full e-flex e-con e-child\" data-id=\"c10da65\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f097182 elementor-widget elementor-widget-text-editor\" data-id=\"f097182\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Plan de l\u2019\u00e9tude visant \u00e0 \u00e9valuer les effets d\u2019une suppl\u00e9mentation orale en NMN associ\u00e9e \u00e0 une activit\u00e9 physique d\u2019intensit\u00e9 mod\u00e9r\u00e9e. Effets de l\u2019exercice a\u00e9robie associ\u00e9 \u00e0 une suppl\u00e9mentation orale en NMN (n = 20), compar\u00e9s \u00e0 ceux de l\u2019exercice a\u00e9robie seul (n = 21), sur le taux veineux de NAD+. Les barres d\u2019erreur repr\u00e9sentent l\u2019\u00e9cart-type (ET) de chaque groupe. La significativit\u00e9 a \u00e9t\u00e9 d\u00e9termin\u00e9e \u00e0 l\u2019aide d\u2019un test t : * p &lt; 0,05 ; ** p &lt; 0,01 ; *** p &lt; 0,001 ; **** p &lt; 0,0001.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1b7e762 e-con-full e-flex e-con e-child\" data-id=\"1b7e762\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b759be1 elementor-widget elementor-widget-image\" data-id=\"b759be1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"792\" height=\"305\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img2.png\" class=\"attachment-large size-large wp-image-28577\" alt=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img2.png 792w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img2-300x116.png 300w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/NMN-img2-768x296.png 768w\" sizes=\"(max-width: 792px) 100vw, 792px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bd646f6 e-flex e-con-boxed e-con e-parent\" data-id=\"bd646f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2b5ee68 elementor-widget elementor-widget-text-editor\" data-id=\"2b5ee68\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Niveaux d\u2019expression relatifs des g\u00e8nes associ\u00e9s au m\u00e9tabolisme du NAD+ chez les sujets r\u00e9pondeurs et non-r\u00e9pondeurs \u00e0 la suppl\u00e9mentation en NMN. (a) Taux de NAD+ dans le sang total mesur\u00e9s chez les r\u00e9pondeurs et les non-r\u00e9pondeurs apr\u00e8s 30 jours de suppl\u00e9mentation en NMN \u00e0 raison de 1 000 mg\/jour. (b) Le profil d\u2019expression des g\u00e8nes associ\u00e9s au m\u00e9tabolisme du NAD+ a \u00e9t\u00e9 obtenu par s\u00e9quen\u00e7age des PBMC isol\u00e9es \u00e0 partir du sang veineux pr\u00e9lev\u00e9 \u00e0 la fin de l\u2019\u00e9tude clinique chez quatre sujets r\u00e9pondeurs et quatre sujets non-r\u00e9pondeurs, class\u00e9s selon leurs taux de NAD+ mesur\u00e9s. Les barres d\u2019erreur repr\u00e9sentent l\u2019\u00e9cart-type (ET). La significativit\u00e9 a \u00e9t\u00e9 calcul\u00e9e \u00e0 l\u2019aide d\u2019un test t pour (a) : **** p &lt; 0,0001.    <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Effets du NMN et de l\u2019exercice physique chez les personnes d\u2019\u00e2ge moyen et les personnes \u00e2g\u00e9es R\u00e9sultats : Dans le cadre d\u2019un essai clinique contr\u00f4l\u00e9 par placebo et men\u00e9 en double aveugle afin d\u2019\u00e9valuer les effets du NMN et de l\u2019exercice a\u00e9robie, nous avons d\u00e9montr\u00e9 qu\u2019une suppl\u00e9mentation orale en NMN (500 mg\/jour ou 1 000 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-28575","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/pages\/28575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/comments?post=28575"}],"version-history":[{"count":0,"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/pages\/28575\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/media?parent=28575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}