{"id":28581,"date":"2026-07-02T05:26:13","date_gmt":"2026-07-02T09:26:13","guid":{"rendered":"https:\/\/www.celfull.com\/etudes-cliniques-sur-le-nad"},"modified":"2026-08-25T23:53:46","modified_gmt":"2026-08-26T03:53:46","slug":"etudes-cliniques-sur-le-nad","status":"publish","type":"page","link":"https:\/\/www.celfull.com\/fr\/etudes-cliniques-sur-le-nad","title":{"rendered":"\u00c9tudes cliniques sur le NAD+"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"28581\" class=\"elementor elementor-28581 elementor-26895\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f8d98e0 e-flex e-con-boxed e-con e-parent\" data-id=\"f8d98e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bbf50ae elementor-widget elementor-widget-shortcode\" data-id=\"bbf50ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9cbced1 e-flex e-con-boxed e-con e-parent\" data-id=\"9cbced1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2c26d8f elementor-widget elementor-widget-heading\" data-id=\"2c26d8f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Variabilit\u00e9 et dynamique du NAD+ en conditions r\u00e9elles<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-00c2388 e-flex e-con-boxed e-con e-parent\" data-id=\"00c2388\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d93b2d1 e-con-full e-flex e-con e-child\" data-id=\"d93b2d1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8273722 elementor-widget elementor-widget-text-editor\" data-id=\"8273722\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>R\u00e9sultats :<\/h3><div class=\"ytable\"><div class=\"ytable-cell txt\"><p>Nous avons mesur\u00e9 les niveaux de NAD+ dans le sang total de personnes n\u2019ayant jamais pris de compl\u00e9ments de NAD+, dont 75 femmes et 67 hommes r\u00e9partis dans diff\u00e9rents groupes d\u2019\u00e2ge. La comparaison entre les sexes a r\u00e9v\u00e9l\u00e9 que les femmes pr\u00e9sentaient en moyenne un niveau de NAD+ sanguin total inf\u00e9rieur \u00e0 celui des hommes : 27,2 \u00b1 10,3 \u00b5M contre 32,5 \u00b1 16,3 \u00b5M. L\u2019\u00e9tude a \u00e9galement montr\u00e9 que, chez les deux sexes, les participants \u00e2g\u00e9s de 20 \u00e0 50 ans pr\u00e9sentaient des niveaux de NAD+ significativement plus \u00e9lev\u00e9s que ceux \u00e2g\u00e9s de 50 \u00e0 85 ans. La diminution du NAD+ li\u00e9e \u00e0 l\u2019\u00e2ge \u00e9tait plus marqu\u00e9e chez les hommes, avec une moyenne passant de 44,2 \u00b1 18,9 \u00b5M \u00e0 25,9 \u00b1 9,8 \u00b5M (p &lt; 0,0001). Chez les femmes, cette diminution \u00e9tait moins importante, les niveaux passant de 32,7 \u00b1 9,6 \u00b5M \u00e0 24,8 \u00b1 9,6 \u00b5M (p &lt; 0,05). En outre, l\u2019\u00e9cart entre les sexes \u00e9tait plus prononc\u00e9 chez les participants de moins de 50 ans, mais n\u2019\u00e9tait plus significatif chez ceux \u00e2g\u00e9s de plus de 50 ans.     <\/p><p>Afin d\u2019\u00e9tudier les fluctuations \u00e0 long terme du NAD+ en conditions r\u00e9elles, nous avons mesur\u00e9 les niveaux de NAD+ de six sujets deux fois par semaine pendant plus de 100 jours, tout en enregistrant les principaux changements li\u00e9s \u00e0 leur alimentation, \u00e0 leur activit\u00e9 physique et \u00e0 leur sommeil. Les r\u00e9sultats ont montr\u00e9 que les niveaux de NAD+ restaient globalement stables pendant les 100 jours de suivi, \u00e0 l\u2019exception d\u2019un participant ayant commenc\u00e9 spontan\u00e9ment une suppl\u00e9mentation en NMN. Chez ce sujet, le niveau de NAD+ capillaire a augment\u00e9 de mani\u00e8re notable, passant de 32,9 \u00b5M \u00e0 47,3 \u00b5M (p &lt; 0,0001). Un autre sujet pratiquait r\u00e9guli\u00e8rement une activit\u00e9 physique, enregistr\u00e9e lors de 11 des 25 jours de mesure du NAD+. Ses niveaux de NAD+ \u00e9taient significativement plus \u00e9lev\u00e9s les jours d\u2019exercice que les jours sans activit\u00e9 physique. Cette augmentation n\u2019a toutefois pas \u00e9t\u00e9 observ\u00e9e chez un sujet pratiquant moins fr\u00e9quemment une activit\u00e9 physique, celle-ci n\u2019ayant \u00e9t\u00e9 enregistr\u00e9e que 3 jours sur 24. Les autres \u00e9v\u00e9nements observ\u00e9s, notamment le manque de sommeil, les menstruations et la prise orale de phosphatidylcholine (PPC) ou de silibinine, n\u2019ont pas eu d\u2019effet significatif sur les niveaux de NAD+ capillaire.    <\/p><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-659f48e e-con-full e-flex e-con e-child\" data-id=\"659f48e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aaa921d elementor-widget elementor-widget-image\" data-id=\"aaa921d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"480\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141104202.jpg\" class=\"attachment-large size-large wp-image-28564\" alt=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141104202.jpg 800w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141104202-300x180.jpg 300w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-241029141104202-768x461.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bf817a3 e-flex e-con-boxed e-con e-parent\" data-id=\"bf817a3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e46675b e-con-full e-flex e-con e-child\" data-id=\"e46675b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9eabee0 elementor-widget elementor-widget-image\" data-id=\"9eabee0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"700\" height=\"353\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-240Z615452U29.png\" class=\"attachment-large size-large wp-image-28582\" alt=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-240Z615452U29.png 700w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-240Z615452U29-300x151.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-184b4c4 e-con-full e-flex e-con e-child\" data-id=\"184b4c4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-55dc8ee elementor-widget elementor-widget-text-editor\" data-id=\"55dc8ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>(c) Protocole d\u2019\u00e9tude destin\u00e9 \u00e0 mesurer les niveaux de NAD+ dans le sang pr\u00e9lev\u00e9 au bout du doigt chez des volontaires en bonne sant\u00e9 de diff\u00e9rents \u00e2ges et sexes. (d) Dans cette \u00e9tude, les participantes (n = 75) pr\u00e9sentaient un niveau de NAD+ significativement inf\u00e9rieur \u00e0 celui des participants masculins (n = 67). (e) Chez les hommes comme chez les femmes, le groupe \u00e2g\u00e9 de 50 \u00e0 85 ans pr\u00e9sentait des niveaux de NAD+ significativement inf\u00e9rieurs \u00e0 ceux du groupe \u00e2g\u00e9 de 18 \u00e0 50 ans. Dans le groupe des 18\u201350 ans, les hommes pr\u00e9sentaient un niveau de NAD+ sup\u00e9rieur \u00e0 celui des femmes, tandis qu\u2019aucune diff\u00e9rence significative n\u2019a \u00e9t\u00e9 observ\u00e9e dans le groupe des 50\u201385 ans. La significativit\u00e9 a \u00e9t\u00e9 d\u00e9termin\u00e9e \u00e0 l\u2019aide d\u2019un test t pour la partie (d) et d\u2019une analyse de variance \u00e0 deux facteurs pour la partie (e) : * p &lt; 0,05 ; ** p &lt; 0,01 ; **** p &lt; 0,0001.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3495724 e-flex e-con-boxed e-con e-parent\" data-id=\"3495724\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-281c9d5 e-con-full e-flex e-con e-child\" data-id=\"281c9d5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bcf217b elementor-widget elementor-widget-text-editor\" data-id=\"bcf217b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>(d) Sch\u00e9ma du suivi \u00e0 long terme des niveaux de NAD+. Les \u00e9v\u00e9nements tels que l\u2019activit\u00e9 physique, le manque de sommeil, la prise de m\u00e9dicaments, les menstruations et la suppl\u00e9mentation alimentaire ont \u00e9t\u00e9 enregistr\u00e9s au moyen d\u2019un questionnaire. (e) Dynamique du NAD+ mesur\u00e9e chez six participants pendant plus de trois mois. F et M d\u00e9signent respectivement les femmes et les hommes. (f) Distribution des niveaux de NAD+ mesur\u00e9s au bout du doigt pendant le suivi \u00e0 long terme. (g) Effets des diff\u00e9rents \u00e9v\u00e9nements sur les niveaux de NAD+ de chaque sujet. La prise de NMN et l\u2019activit\u00e9 physique ont significativement augment\u00e9 les niveaux de NAD+ chez les sujets 3 et 6, respectivement. Seuls les jours au cours desquels un \u00e9v\u00e9nement pr\u00e9cis avait \u00e9t\u00e9 enregistr\u00e9 ont \u00e9t\u00e9 pris en compte ; les jours comportant plusieurs \u00e9v\u00e9nements ont \u00e9t\u00e9 exclus de l\u2019analyse. La significativit\u00e9 a \u00e9t\u00e9 d\u00e9termin\u00e9e \u00e0 l\u2019aide d\u2019un test t pour la partie (c) ainsi que pour les sujets 4 et 6 de la partie (g). Une analyse de variance \u00e0 deux facteurs a \u00e9t\u00e9 utilis\u00e9e pour les sujets 1, 2, 3 et 5 de la partie (g) : * p &lt; 0,05 ; **** p &lt; 0,0001.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f05ff9e e-con-full e-flex e-con e-child\" data-id=\"f05ff9e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d78255b elementor-widget elementor-widget-image\" data-id=\"d78255b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"700\" height=\"550\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-240Z615461O92.png\" class=\"attachment-large size-large wp-image-28583\" alt=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-240Z615461O92.png 700w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/1-240Z615461O92-300x236.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Variabilit\u00e9 et dynamique du NAD+ en conditions r\u00e9elles R\u00e9sultats : Nous avons mesur\u00e9 les niveaux de NAD+ dans le sang total de personnes n\u2019ayant jamais pris de compl\u00e9ments de NAD+, dont 75 femmes et 67 hommes r\u00e9partis dans diff\u00e9rents groupes d\u2019\u00e2ge. La comparaison entre les sexes a r\u00e9v\u00e9l\u00e9 que les femmes pr\u00e9sentaient en moyenne un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-28581","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/pages\/28581","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/comments?post=28581"}],"version-history":[{"count":0,"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/pages\/28581\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.celfull.com\/fr\/wp-json\/wp\/v2\/media?parent=28581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}