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# CELFULL BIO-TECH (USA) INC.: CELFULL is an AI-driven longevity and aging research platform focused on aging biology, NAD+ metabolism, and science-based healthspan innovation.

## Sitemaps
[XML Sitemap](https://www.celfull.com/sitemap_index.xml): Includes all crawlable and indexable pages.

## Pages
- [Distributor](https://www.celfull.com/distributor): Officially authorized exclusive distribution rights for the agreed region, with strict control on cross-region sales to protect your exclusive market and profit margin.
- [Custom](https://www.celfull.com/custom): Whether you're starting with a vision or a fully developed concept, we help bring your ideas to life.
- [Celfavor Technology](https://www.celfull.com/celfavor-technology): Active ingredients are prone to degradation by environmental factors such as humidity, light and air, as well as physiological environments like gastric acid and digestive enzymes. They are largely inactivated before reaching the intestinal absorption site, resulting in low bioavailability.
- [Celfavor PQQ](https://www.celfull.com/celfavor-pqq): ✖
- [Celfavor Q10](https://www.celfull.com/celfavor-q10): ✖
- [Celfavor NMNH](https://www.celfull.com/celfavor-nmnh): Ordinary NMNH has highly unstable chemical properties and is easily oxidized and degraded by light, temperature, humidity, air contact and gastric acid, greatly limiting its wide application.
- [Celfavor NADH](https://www.celfull.com/celfavor-nadh): Conventional NADH is highly unstable and prone to oxidative degradation by light, temperature, humidity, air and gastric acid. Its degradation rate exceeds 70% within one month at room temperature, limiting its application.
- [News](https://www.celfull.com/cnews): skip render: ucaddon_post_blocks skip render: ucaddon_post_blocks skip render: ucaddon_archive_pagination
- [Related Cases NAD+](https://www.celfull.com/related-cases-nad): We mapped the whole blood NAD+ levels of NAD+ supplement-naive people including 75females and 67 males across different age groups. The cross-gender comparisonindicated that females have on average a lower whole blood NAD+ level (27.2 ± 10.3 μM)compared to males (32.5 +16.3yM). The survey further revealed that participantsbetween 20 and 50 years of age have significantly higher NAD+ content than those agedbetween 50 and 85 for both genders. Notably, the age-related NAD+ decline is moresevere for males with the average NAD+ level decreased from 44.2 + 18.9 μM to 25.9 + 9.8yM (p< 0.0001). While for females, the NAD+ content is decreased by a lesser extent from32.7 + 9.6 pM to 24.8 + 9.6 yM with p<0.05. Moreover, the gender x0002 related NAD+disparity is more pronounced for participants younger than 50 years of age, but notsignificant for those aged over 50.
- [Related Cases NMN](https://www.celfull.com/related-cases-nmn): In a placebo-controlled, double blind clinical trial to assess the effect of NMN and aerobic sport. We showed that oral NMN supplementation (500 mg/day or 1000 mg/day) for 30 days can significantly increase whole-blood NAD+ levels in a dose-dependent manner, and aerobic sport can further increase NAD+ levels both in control group and NMN treated group.
- [Products Evaluation and Clinical Research Platform](https://www.celfull.com/products-evaluation-and-clinical-research): The Clinical Research Platform is centered around assessing the effects of anti-aging interventions on the human body. This encompasses studies on pharmacokinetics, pharmacodynamics, tolerance, and safety, conducted through randomized, placebo-controlled, parallel-design trials. The outcomes of these clinical trials are fundamental in supporting the development of anti-aging products, whether as medicines or dietary supplements. To date, CELFULL and its partners have successfully completed multiple clinical trials.
- [TurnA Drug Delivery Platform](https://www.celfull.com/turn-a-drug-delivery): The TURN A drug delivery system enhances the absorption, biodistribution, and bioavailability of aging intervention compounds through advanced technologies like intermolecular encapsulation, complexation/chelation, nanoemulsion dispersion, biomembrane penetration, and nano-drug carriers. These methods protect the compounds from degradation, increase their solubility and stability, and facilitate transport across biological barriers.
- [AI Network Pharmacology Platform](https://www.celfull.com/ai-network-pharmacology): Our AI Network Pharmacology Platform includes:
- [Aging Mechanism Research Platform](https://www.celfull.com/aging-mechanism-research): Aging is a multifaceted process resulting from complex changes in biological functions, ranging from DNA damage accumulation to protein dysfunction and altered intercellular communication. Our research focuses on deciphering these mechanisms at genomic, cellular, and systemic levels. This is the fundamental step towards identifying effective strategies to slow aging and enhance healthy lifespan.
- [Pipeline](https://www.celfull.com/pipeline): At CELFULL, we are advancing our leading programs across three key areas: therapeutic agents addressing medical challenges with significant unmet needs, nutraceutical agents designed to counteract aging-related weaknesses and functional degradation in human organs, and skincare agents formulated to maintain a youthful glow at any age. Our unwavering commitment lies in deepening our understanding of the cell biology that controls aging, enabling us to develop interventions for longer, healthier, and more fulfilling lives.
- [Publications](https://www.celfull.com/publications): Research achievements of the CELFULL research team Li, H., Chang, Y. Y., Lee, J. Y., Bahar, I., & Yang, L. W., DynOmics: dynamics of structural proteome and beyond. Nucleic acids research, 45(W1), W374-W380(2017) Read More Zhang, S., Li, H., Krieger, J. M., & Bahar, I., Shared signature dynamics tempered by local fluctuations enables fold adaptability and specificity. Molecular biology and evolution, 36(9), 2053-2068(2019) Read More Li, H., Pei, F., Taylor, D. L., & Bahar, I., QuartataWeb: integrated chemical–protein-pathway mapping for polypharmacology and chemogenomics. Bioinformatics, 36(12), 3935-3937(2020) Read More Song, X., Zhou, Z., Li, H., Xue, Y., Lu, X., Bahar, I., ... & Wan, Y., Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers. Cancer Discov (2020) 10 (12): 1872–1893. Read More Tsai, C. Y., Salawu, E. O., Li, H., Lin, G. Y., Kuo, T. Y., Voon, L., ... & Yang, L. W., Helical structure motifs made searchable for functional peptide design. Nature Communications, 13(1), 102(2022) Read More Li, R.; Jiang, F.; Xiao, Q.; Li, J.; Liu, X.; Yu, Q.; Liu, Y.; Zeng, C., Microcalorimetric, spectroscopic and microscopic investigation on the toxic effects of CdTe quantum dots on Halobacterium halobium R1.Nanotechnology, 21(47), (2010) Read More Han, X.; Lai, L.; Tian, F.; Jiang, F. L.; Xiao, Q.; Li, Y.; Yu, Q.; Li, D.; Wang, J.; Zhang, Q.; Zhu, B.; Li, R.; Liu, Y., Toxicity of CdTe quantum dots on yeast Saccharomyces cerevisiae. Small, 8 (17), 2680-2698(2012) Read More Han, X. L.; Tian, F. F.; Ge, Y. S.; Jiang, F. L.; Lai, L.; Li, D. W.; Yu, Q.; Wang, J.; Lin, C.; Liu, Y., Spectroscopic, structural and thermodynamic properties of chlorpyrifos bound to serum albumin:A comparative study between BSA and HSA. Journal of Photochemistry and Photobiology B: Biology, 109, 1-11(2012) Read More Wang P, Chen M, Hou Y, et al. Fingerstick blood assay maps real‐world NAD+ disparity across gender and age. Aging Cell, 2023, 22(10): e13965. Read More Chen, L., Chen, M., Luo, M., Li, Y., Liao, B., Hu, M., & Yu, Q., Ratiometric NAD+ sensors reveal subcellular NAD+ modulators. ACS sensors, 8(4), 1518-1528 (2022) Read More Yu, Q.; Pourmandi, N.; Xue, L.; Gondrand, C.; Fabritz, S.; Bardy, D.; Patiny, L.; Katsyuba, E.; Auwerx, J.; Johnsson, K., A biosensor for measuring NAD(+) levels at the point of care. Nat. Metab., 1 (12), 1219-1225 (2019) Read More Yu, Q.; Xue, L.; Hiblot, J.; Griss, R.; Fabritz, S.; Roux, C.; Binz, P. A.; Haas, D.; Okun, J. G.; Johnsson, K., Semisynthetic sensor proteins enable metabolic assays at the point of care. Science, 361 (6407), 1122-1126 (2018) Read More Yu, Q.; Griss, R.; Schena, A.; Johnsson, K., Highly Modular Bioluminescent Sensors for Small Molecules and Proteins. Methods Enzymol., 589, 365-382 (2017) Read More Xue, L.; Yu, Q.; Griss, R.; Schena, A.; Johnsson, K., Bioluminescent Antibodies for Point-of-Care Diagnostics. Angew. Chem. Int. Ed. Engl., 56 (25), 7112-7116 (2017) Read More Hiblot, J.; Yu, Q.; Sabbadini, M. D. B.; Reymond, L.; Xue, L.; Schena, A.; Sallin, O.; Hill, N.; Griss, R.; Johnsson, K., Luciferases with Tunable Emission Wavelengths. Angew. Chem. Int. Ed. Engl., 56 (46), 14556-14560 (2017) Read More Zhang, J.; Li, R.; Jiang, F. L.; Zhou, B.; Luo, Q. Y.; Yu, Q.; Han, X. L.; Lin, Y.; He, H.; Liu, Y.; Wang, Y. L., An electrochemical and surface plasmon resonance study of adsorption actions of DNA by Escherichia coli. Colloids Surf. B Biointerfaces, 117, 68-74 (2014) Read More Gasilova, N.#; Yu, Q.#; Qiao, L.; Girault, H. H., On-chip spyhole mass spectrometry for droplet-based microfluidics. Angew. Chem. Int. Ed. Engl., 53 (17), 4408-12 (2014) Read More Dong, J. X.; Zhao, G. Y.; Yu, Q.; Li, R.; Yuan, L.; Chen, J.; Liu, Y., Mitochondrial dysfunction induced by honokiol. J. Membr. Biol., 246 (5), 375-81 (2013) Read More
- [Careers](https://www.celfull.com/careers): Our team work with passion and mission, we share the same goal - to solve aging and aging-related diseases and make people live a longer, healthier life, and the solutions should be fair, affordable and available for ordinary beings. At CELFULL, we employ a unique approach that combines AI network pharmacology with aging biology. Our goal is to discover the most promising natural compositions to combat aging and age-related diseases.
- [Research Recruitment](https://www.celfull.com/research-recruitment): NADH, chemically known as nicotinamide adenine dinucleotide, is a vital coenzyme present in every living animal and plant cell. It plays a crucial role in thousands of metabolic reactions within the human body, including the Krebs cycle and the electron transport chain. NADH's importance in gene repair, immunity enhancement, anti-oxidation, and sleep improvement makes it a highly valuable substance for bodily functions.
- [Contact](https://www.celfull.com/contact): What makes CELFULL NADH different from other NAD+ supplements on the market?
- [Company](https://www.celfull.com/company): At CELFULL, we employ a unique approach that combines AI network pharmacology with aging biology. Our goal is to discover the most promising natural compositions to combat aging and age-related diseases.
- [Home](https://www.celfull.com/): Rooted in two decades of scientific progress, CELFULL's platform integrates three core pillars:
- [Privacy Policy](https://www.celfull.com/privacy-policy): CELFULL ("we", "us", or "our") operates the website www.celfull.com (the "Service"). This Privacy Policy explains how we collect, use, disclose, and safeguard your information when you visit our website, including any other media form, media channel, mobile website, or mobile application related or connected thereto.

## Forms
- [Distributor Recruitment Form](https://www.celfull.com/form/distributor-recruitment-form)
- [Contact Form](https://www.celfull.com/form/simple-contact-form)

CELFULL is a leader in evidence-based anti-aging innovative drug development, with operations spanning two core sectors: clinical-stage pharmaceutical R&D, and consumer wellness, including nutritional supplements and holistic health solutions. CELFULL provides the world's most stable patented NADH raw materials, as well as sustained-release formulation solutions for a broad spectrum of active ingredients.

Celfavor® is  an Next-Generation Microsphere Controlled Release Technology Developed by CEFLULL. Celfavor® technology has been patented in 7 key global markets. Celfavor® Technology is An Innovative Solution for Nutrient Delivery Systems.
Core Pain Points of Traditional Nutritional Supplements:
1. Most Active Ingredients Never Reach Where It Matters: Active ingredients are prone to degradation by environmental factors such as humidity, light and air, as well as physiological environments like gastric acid and digestive enzymes. They are largely inactivated before reaching the intestinal absorption site, resulting in low bioavailability.

Process Flowchart: Unstable in Storage -> Degraded in the stomach -> Lost before intestinal absorption

2. Limited Absorption Efficiency: Active ingredients are released instantaneously, leading to incomplete absorption by intestinal mucosa, or transient surge in blood drug concentration, making it impossible to achieve steady-state and efficient utilization.

3. Poor Consumption Experience: Some active ingredients have bitter, metallic or other unpleasant tastes, directly affecting user compliance and terminal experience.

4. Poor Compounding Compatibility: Antagonistic effects easily occur between different active ingredients, leading to weakened activity and offset efficacy. They are unsuitable for complex formulations, limiting product function expansion and industrial application.

5. Imbalanced Dose-Efficiency: Blindly increasing the dose to compensate for absorption defects not only raises product costs but also increases the metabolic burden on the kidneys, posing potential health risks.

The above pain points have trapped nutritional supplementation in an industrial dilemma of high input and low conversion, driving the need for innovative breakthroughs and industrial upgrades in advanced delivery technologies.

Celfavor® Microsphere Controlled Release Technology:
1. Celfavor® is a professional stable delivery technology platform for active ingredients developed by the CELFULL R&D team through years of research, which solves core problems of traditional dietary supplements such as poor stability and low absorption efficiency.
2. Using natural food-grade stabilizers combined with innovative microsphere carrier technology, we fundamentally solve the stability and delivery challenges of active ingredients, greatly improving formulation stability and efficacy.

Five Core Advantages of Celfavor® Technology
1. Excellent Stability: It provides a 36-month shelf life, withstands gastric acid for up to 4 hours, maintains nearly 100% structural integrity and biological potency of active ingredients, and fundamentally eliminates the issue of ingredient inactivation.
2. Targeted High-Efficiency Absorption: Featuring an intestinal-targeted sustained-release system, it releases precisely in the intestinal tract, enhancing nutrient absorption and bioavailability to achieve high efficacy at low doses.
3. Excellent Taste Optimization: By leveraging microsphere carrier technology to precisely encapsulate active ingredients, the technology masks bitter, metallic, and other unpleasant tastes and odors, enhances palatability and consumer compliance, and delivers an optimized consumption experience.
4. Precise Dose Efficiency Enhancement: Backed by targeted, high-efficiency absorption, nutrient bioavailability is significantly enhanced. This enables ideal supplementation outcomes at low doses, reducing costs, alleviating renal burden, and eliminating health risks associated with high dosages.
5. Broad-Spectrum Formula Compatibility: The technology exhibits no antagonistic reactions with a wide range of functional active ingredients, delivering excellent compatibility. It can flexibly meet the requirements of multi-category, multi-functional compound formulas, with strong industrial applicability.

This technology uses green processes and natural raw materials, with zero pollution and zero emissions during production, in line with the global concept of sustainable development. Its exclusive preparation process has been granted invention patents in seven major core markets worldwide, and its technological originality and foresight have been internationally recognized.