{"id":29687,"date":"2026-05-29T10:38:09","date_gmt":"2026-05-29T14:38:09","guid":{"rendered":"https:\/\/www.celfull.com\/%e6%9c%aa%e5%88%86%e9%a1%9e\/gut-microbiota-nad-metabolism-symbiosis.html"},"modified":"2026-05-29T10:38:09","modified_gmt":"2026-05-29T14:38:09","slug":"gut-microbiota-nad-metabolism-symbiosis","status":"publish","type":"post","link":"https:\/\/www.celfull.com\/zh-hant\/%e6%96%b0%e8%81%9e\/gut-microbiota-nad-metabolism-symbiosis.html","title":{"rendered":"\u5bbf\u4e3b\u8207\u8178\u9053\u83cc\u7fa4\u7684\u4e92\u5229\u5171\u751f\uff1aNAD+ \u4ee3\u8b1d\u7684\u96b1\u85cf\u5bc6\u78bc"},"content":{"rendered":"
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\u8178\u9053\u83cc\u7fa4\u5982\u4f55\u8abf\u7bc0\u5bbf\u4e3b\u7684 NAD+ \u4ee3\u8b1d\u5faa\u74b0<\/h3>\n<\/div>\n<\/div>\n
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\u904e\u5f80\u7814\u7a76\u5df2\u8b49\u5be6\uff0c\u53e3\u670d NMN \u548c NR \u7121\u6cd5\u76f4\u63a5\u63d0\u9ad8\u4eba\u9ad4\u8840\u6db2\u4e2d\u7684\u4ee3\u8b1d\u7269\u6c34\u5e73\u3002\u5b83\u5011\u7684\u6548\u679c\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4f9d\u8cf4\u8178\u9053\u83cc\u7fa4\u6240\u9032\u884c\u7684\u8f49\u5316\u3002\u9019\u4e9b\u5fae\u751f\u7269\u628a NMN \u548c NR \u8f49\u5316\u70ba\u7159\u9178 \u2014\u2014 \u7159\u9178\u662f\u6838\u5fc3\u7d30\u80de\u4ee3\u8b1d\u7684\u4e3b\u8981\u5faa\u74b0\u524d\u9ad4\u3002\u4e00\u65e6\u88ab\u7d30\u80de\u5438\u6536\uff0c\u7159\u9178\u4fbf\u6703\u901a\u904e Preiss-Handler \u9014\u5f91\u9ad8\u6548\u5730\u7522\u751f\u6709\u6548\u80fd\u91cf\u5e95\u7269\uff0c\u4e0d\u53d7\u9650\u901f\u9176\u7684\u9650\u5236\u3002 <\/div>\n
\u8178\u9053\u83cc\u7fa4\u9060\u4e0d\u6b62\u662f\u7c21\u55ae\u7684\u8f49\u5316\u5de5\u5177\u3002\u5b83\u5011\u8207\u4eba\u9ad4\u5bbf\u4e3b\u5efa\u7acb\u8d77\u4e92\u5229\u5171\u751f\u7684\u95dc\u4fc2\u3002\u5728\u628a NMN \u548c NR \u5206\u89e3\u70ba\u7159\u9178\u7684\u540c\u6642\uff0c\u5fae\u751f\u7269\u4e5f\u6703\u4fc3\u9032\u77ed\u93c8\u8102\u80aa\u9178\u7684\u7522\u751f\u4e26\u964d\u4f4e\u8178\u9053 pH \u503c\uff0c\u70ba\u81ea\u8eab\u7e41\u6b96\u5275\u9020\u6709\u5229\u689d\u4ef6\u3002NR \u50be\u5411\u65bc\u7279\u5225\u4fc3\u9032 Enterocloster aldensis \u7684\u751f\u9577\uff0c\u800c NMN \u5247\u5c0d\u6574\u9ad4\u8178\u9053\u83cc\u7fa4\u7d44\u6210\u767c\u63ee\u66f4\u5ee3\u6cdb\u7684\u8abf\u7bc0\u4f5c\u7528\u3002 <\/div>\n<\/div>\n<\/div>\n
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\u5373\u4f7f\u6c92\u6709\u5916\u90e8\u88dc\u5145\uff0c\u9ad4\u5167\u4e5f\u6301\u7e8c\u904b\u884c\u8457\u4e00\u5957\u5929\u7136\u4ee3\u8b1d\u5e95\u7269\u56de\u6536\u7cfb\u7d71\u3002\u5167\u6e90\u6027\u80fd\u91cf\u4ee3\u8b1d\u7269\u88ab sirtuins\u3001CD38 \u548c PARPs \u6d88\u8017\uff0c\u7522\u751f\u7159\u9170\u80fa\u4f5c\u70ba\u526f\u7522\u7269\u3002\u9019\u7a2e\u4ee3\u8b1d\u5ee2\u7269\u6d41\u5165\u8178\u9053\uff0c\u5728\u5fae\u751f\u7269\u4f5c\u7528\u4e0b\u8f49\u5316\u70ba\u7159\u9178\uff0c\u518d\u91cd\u65b0\u9032\u5165\u9ad4\u5faa\u74b0\uff0c\u4ee5\u7dad\u6301\u8eab\u9ad4\u57fa\u672c\u7684\u4ee3\u8b1d\u5132\u5099\u3002 <\/div>\n<\/div>\n<\/div>\n
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\uff08\u4f86\u6e90\uff1aScience Advances, 2025\uff09<\/strong><\/div>\n
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\u4e26\u975e\u6240\u6709\u7159\u9170\u80fa\u90fd\u9700\u8981\u7d93\u5fae\u751f\u7269\u8f49\u5316\u624d\u80fd\u6b63\u5e38\u767c\u63ee\u4f5c\u7528\u3002\u90e8\u5206\u7159\u9170\u80fa\u901a\u904e\u8840\u6db2\u5faa\u74b0\u5230\u9054\u9aa8\u9abc\u808c\u548c\u795e\u7d93\u7d44\u7e54\uff0c\u5728\u90a3\u88e1\u7d93\u7531\u88dc\u6551\u9014\u5f91\u53c3\u8207\u4ee3\u8b1d\u7269\u5408\u6210\u3002\u9019\u689d\u9014\u5f91\u53d7\u5230\u9650\u901f\u9176 NAMPT \u7684\u56b4\u683c\u63a7\u5236\u3002\u6b63\u56e0\u5982\u6b64\uff0c\u53e3\u670d\u548c\u6ce8\u5c04\u7684\u524d\u9ad4\u88dc\u5145\u54c1\u5728\u63d0\u9ad8\u9aa8\u9abc\u808c\u5167\u7684\u808c\u8089\u4ee3\u8b1d\u542b\u91cf\u65b9\u9762\u6548\u679c\u6709\u9650\u3002 <\/div>\n
\u9019\u4e9b\u767c\u73fe\u70ba\u6297\u8870\u8001\u5be6\u8e10\u63d0\u4f9b\u4e86\u65b0\u7684\u6307\u5c0e\u3002\u8981\u901a\u904e\u4ee3\u8b1d\u76f8\u95dc\u6a5f\u5236\u6539\u5584\u808c\u8089\u6a5f\u80fd\uff0c\u4eba\u5011\u9700\u8981\u512a\u5316\u524d\u9ad4\u9078\u64c7\u548c\u65e5\u5e38\u4fdd\u5065\u65b9\u6848\u3002\u846b\u8606\u5df4\u9e7c\u548c NADH \u7b49\u7279\u6b8a\u524d\u9ad4\u662f\u53ef\u884c\u7684\u9078\u64c7\u3002\u9069\u5ea6\u7684\u9ad4\u80b2\u935b\u7149\u914d\u5408\u88dc\u5145\uff0c\u53ef\u63d0\u9ad8\u5408\u6210\u6548\u7387\u4e26\u7522\u751f\u5354\u540c\u5065\u5eb7\u6548\u76ca\u3002 <\/div>\n
\u6df1\u5165\u7814\u7a76\u63ed\u793a\uff0c\u8178\u9053\u83cc\u7fa4\u662f\u4eba\u9ad4\u5bbf\u4e3b\u4e0d\u53ef\u6216\u7f3a\u7684\u5171\u751f\u5925\u4f34\u3002\u8178\u9053\u5065\u5eb7\u7121\u7591\u5c07\u6210\u70ba\u672a\u4f86\u7cfb\u7d71\u6027\u6297\u8870\u8001\u7b56\u7565\u7684\u6838\u5fc3\u7d44\u6210\u90e8\u5206\u3002 <\/div>\n<\/div>\n

\u53c3\u8003\u6587\u737b<\/strong>
\nYaku K, Palikhe S, Iqbal T, et al. Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation[J]. Science Advances, 2025, 11(12): eadr1538. <\/strong>
\nChellappa K, McReynolds M R, Lu W, et al. NAD precursors cycle between host tissues and the gut microbiome[J]. Cell metabolism, 2022, 34(12): 1947-1959. e5. <\/strong><\/div>\n

Disclaimer<\/strong>
\nThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.<\/strong><\/div>\n
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