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01 \u58fd\u547d\u8207\u5065\u5eb7\u58fd\u547d\u4e4b\u9593\u7684\u5dee\u8ddd<\/strong><\/p>\n\n

\u514d\u75ab\u5e73\u8861\uff0c\u800c\u975e\u66f4\u5f37\u7684\u514d\u75ab\u529b\uff0c\u53ef\u80fd\u662f\u6d3b\u5f97\u66f4\u4e45\u3001\u66f4\u5065\u5eb7\u7684\u95dc\u9375\u3002\u96a8\u8457\u5168\u7403\u9810\u671f\u58fd\u547d\u4e0a\u5347\uff0c\u300c\u6d3b\u4e86\u591a\u4e45\u300d\u8207\u300c\u5065\u5eb7\u5730\u6d3b\u4e86\u591a\u4e45\u300d\u4e4b\u9593\u7684\u5dee\u8ddd\u6301\u7e8c\u64f4\u5927\u3002 <\/strong><\/p>\n\n

\u6839\u64da 2024 \u5e74 CDC \u6578\u64da\uff0c\u7f8e\u570b\u9810\u671f\u58fd\u547d\u9054\u5230 79.0 \u6b72\uff0c\u5973\u6027\u5e73\u5747 81.4 \u6b72\uff0c\u7537\u6027 76.5 \u6b72\u3002\u5728\u65e5\u672c\uff0c\u9810\u671f\u58fd\u547d\u8d85\u904e 85 \u6b72\u3002\u7136\u800c\u4eba\u5011\u5728\u665a\u5e74\u5e73\u5747\u6709 8 \u81f3 10 \u5e74\u8655\u65bc\u5065\u5eb7\u6b20\u4f73\u7684\u72c0\u614b\u3002\u300c\u6d3b\u5f97\u9577\u300d\u548c\u300c\u6d3b\u5f97\u597d\u300d\u7684\u4ee3\u78bc\u672a\u5fc5\u53ea\u5b58\u5728\u65bc\u793e\u6703\u6307\u6a19\u4e4b\u4e2d\u3002\u5b83\u5011\u4f3c\u4e4e\u504f\u5411\u67d0\u4e9b\u5bb6\u65cf\uff0c\u9577\u58fd\u8de8\u8d8a\u6578\u4ee3\u4eba\u805a\u96c6\u51fa\u73fe\u3002\u79d1\u5b78\u5bb6\u6307\u51fa\u9577\u58fd\u57fa\u56e0\u5f88\u53ef\u80fd\u662f\u9a45\u52d5\u56e0\u7d20\uff0c\u800c\u514d\u75ab\u5e73\u8861\u6b63\u6210\u70ba\u6838\u5fc3\u4e3b\u984c\u3002 <\/strong><\/p>\n\n

02 \u4e00\u9805\u8de8\u570b\u9577\u58fd\u57fa\u56e0\u7814\u7a76<\/strong><\/p>\n\n

\"\"<\/figure>\n\n

\u7531\u840a\u9813\u5927\u5b78\u91ab\u5b78\u4e2d\u5fc3\u9818\u5c0e\u7684\u8de8\u570b\u7814\u7a76\u5718\u968a\uff0c\u7814\u7a76\u4e86\u591a\u4ee3\u9577\u58fd\u5bb6\u65cf\u3002\u5718\u968a\u5206\u6790\u4e86 212 \u500b\u6709\u591a\u4ee3\u4eba\u9054\u5230\u7570\u5e38\u9ad8\u9f61\u7684\u540c\u80de\u7fa4\u7d44\uff0c\u5c07\u4ed6\u5011\u7684\u57fa\u56e0\u6578\u64da\u8207\u666e\u901a\u4e5d\u5341\u591a\u6b72\u9577\u8005\u9032\u884c\u6bd4\u8f03\u3002 <\/strong><\/p>\n\n

\"\"<\/figure>\n\n

\u901a\u904e\u5168\u57fa\u56e0\u7d44\u7be9\u67e5\uff0c\u4ed6\u5011\u78ba\u5b9a\u4e86\u56db\u500b\u8207\u9577\u58fd\u5bc6\u5207\u76f8\u95dc\u7684\u57fa\u56e0\u7d44\u5340\u57df\u3002\u5728\u9019\u4e9b\u5340\u57df\u5167\uff0c\u4ed6\u5011\u7be9\u9078\u51fa\u4e03\u500b\u5019\u9078\u57fa\u56e0\uff08NUP210L\u3001SLC27A3\u3001CD1A\u3001cGAS\u3001IBTK\u3001RARS2 \u548c SH2D3A\uff09\u4e2d\u7684 12 \u500b\u7f55\u898b\u86cb\u767d\u8cea\u6539\u8b8a\u8b8a\u9ad4\u3002\u6700\u7a81\u51fa\u7684\u767c\u73fe\u662f cGAS \u57fa\u56e0\u4e2d\u7684\u4e00\u500b\u932f\u7fa9\u8b8a\u9ad4\uff0c\u547d\u540d\u70ba rs200818241\u3002\u9019\u500b\u8b8a\u9ad4\u51fa\u73fe\u5728\u5169\u500b\u7121\u89aa\u7de3\u95dc\u4fc2\u7684\u9577\u58fd\u5bb6\u65cf\u4e2d\uff0c\u5728\u666e\u901a\u4eba\u7fa4\u4e2d\u6975\u70ba\u7f55\u898b\u3002<\/strong><\/p>\n\n

03 cGAS\uff1a\u514d\u75ab\u5e73\u8861\u958b\u95dc<\/strong><\/p>\n\n

cGAS \u57fa\u56e0\u7522\u751f\u4e00\u7a2e\u5728\u7d30\u80de\u5167\u5145\u7576 DNA \u50b3\u611f\u5668\u7684\u86cb\u767d\u8cea\u3002\u5728\u6b63\u5e38\u689d\u4ef6\u4e0b\uff0ccGAS \u5075\u6e2c\u7570\u5e38 DNA\uff0c\u4f8b\u5982\u75c5\u6bd2\u611f\u67d3\u6216\u7d30\u80de\u640d\u50b7\u7684\u7247\u6bb5\uff0c\u4e26\u6fc0\u6d3b\u767c\u708e\u53cd\u61c9\u3002\u9019\u7a2e\u53cd\u61c9\u6709\u52a9\u6e05\u9664\u53d7\u640d\u7d30\u80de\u548c\u5c0d\u6297\u75c5\u539f\u9ad4\uff0c\u4fdd\u8b77\u6574\u9ad4\u5065\u5eb7\u3002 <\/strong><\/p>\n\n

\u7136\u800c\u96a8\u8457\u5e74\u9f61\u589e\u9577\uff0c\u53d7\u640d\u7684\u7d30\u80de\u6b98\u9ab8\u4e0d\u65b7\u7d2f\u7a4d\u3002cGAS \u6301\u7e8c\u5075\u6e2c\u9019\u4e9b\u6b98\u9ab8\uff0c\u89f8\u767c\u6301\u7e8c\u3001\u4f4e\u5ea6\u7684\u767c\u708e\u53cd\u61c9\u3002\u79d1\u5b78\u5bb6\u7a31\u4e4b\u70ba\u6162\u6027\u4f4e\u5ea6\u767c\u708e\uff0c\u6709\u6642\u4ea6\u7a31\u70ba\u708e\u6027\u8870\u8001\u3002\u9019\u7a2e\u6301\u7e8c\u7684\u6c89\u9ed8\u767c\u708e\u4fc3\u6210\u9ad8\u8840\u58d3\u3001\u8a8d\u77e5\u8870\u9000\u3001\u95dc\u7bc0\u9000\u5316\u548c\u7d30\u80de\u8870\u8001\uff0c\u9010\u6f38\u4fb5\u8755\u5168\u8eab\u7684\u5668\u5b98\u529f\u80fd\u3002 <\/strong><\/p>\n\n

\u9577\u58fd\u8b8a\u9ad4\u4e26\u975e\u5b8c\u5168\u6d88\u9664 cGAS \u529f\u80fd\uff0c\u800c\u662f\u964d\u4f4e\u86cb\u767d\u8cea\u7a69\u5b9a\u6027\u3002\u9019\u6703\u524a\u5f31 cGAS-STING \u4fe1\u865f\u901a\u8def \u2014\u2014 \u7d30\u80de\u5075\u6e2c DNA \u640d\u50b7\u4e26\u89f8\u767c\u767c\u708e\u7684\u4e3b\u8981\u9014\u5f91\u3002\u7d50\u679c\u662f\u767c\u708e\u53cd\u61c9\u53d7\u5230\u8abf\u7bc0\uff0c\u540c\u6642\u4ecd\u4fdd\u7559\u771f\u6b63\u9700\u8981\u6642\u5075\u6e2c\u5a01\u8105\u548c\u555f\u52d5\u514d\u75ab\u53cd\u61c9\u7684\u57fa\u672c\u80fd\u529b\u3002 <\/strong><\/p>\n\n

04 \u514d\u75ab\u5e73\u8861\uff0c\u800c\u975e\u66f4\u5f37\u7684\u514d\u75ab\u529b<\/strong><\/p>\n\n

\u8207\u9577\u58fd\u76f8\u95dc\u7684 cGAS \u8b8a\u9ad4\u63d0\u4f9b\u4e86\u4e00\u500b\u6709\u529b\u7684\u6a21\u578b\u3002\u5927\u591a\u6578\u4eba\u651c\u5e36\u5169\u500b\u6a19\u6e96 cGAS \u57fa\u56e0\u62f7\u8c9d\u3002\u8b8a\u9ad4\u651c\u5e36\u8005\u64c1\u6709\u81f3\u5c11\u4e00\u500b\u62f7\u8c9d\u7684\u932f\u7fa9\u7a81\u8b8a\uff0c\u53ef\u964d\u4f4e\u86cb\u767d\u8cea\u529f\u80fd\uff0c\u5be6\u969b\u4e0a\u662f\u964d\u4f4e\u767c\u708e\u53cd\u61c9\u800c\u4e0d\u5b8c\u5168\u6d88\u9664\u5b83\u3002 <\/strong><\/p>\n\n

\u9019\u610f\u5473\u8457\u4ed6\u5011\u7684\u8eab\u9ad4\u80fd\u7dad\u6301\u8db3\u5920\u7684\u514d\u75ab\u80fd\u529b\u4f86\u61c9\u5c0d\u611f\u67d3\u548c\u4fee\u5fa9\u7d44\u7e54\u640d\u50b7\uff0c\u540c\u6642\u907f\u514d\u9a45\u52d5\u5e74\u9f61\u76f8\u95dc\u75be\u75c5\u7684\u6162\u6027\u904e\u5ea6\u6fc0\u6d3b\u3002\u7d30\u80de\u5be6\u9a57\u8b49\u5be6\uff0c\u651c\u5e36 cGAS \u8b8a\u9ad4\u7684\u7d30\u80de\u8870\u8001\u5f97\u66f4\u6162\uff0c\u96a8\u6642\u9593\u7d2f\u7a4d\u7684\u8870\u8001\u7d30\u80de\u660e\u986f\u66f4\u5c11\u3002\u5c0f\u9f20\u7d30\u80de\u6a21\u578b\u8b49\u5be6\uff0c\u9019\u7a2e\u6297\u708e\u6548\u679c\u5ef6\u4f38\u5230\u54fa\u4e73\u52d5\u7269\u751f\u7269\u5b78\uff0c\u5f37\u5316\u4e86\u9019\u4e00\u6a5f\u5236\u7684\u9032\u5316\u610f\u7fa9\u3002 <\/strong><\/p>\n\n

\"\"<\/figure>\n\n

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05 \u9081\u5411\u514d\u75ab\u5e73\u8861\u7684\u5be6\u969b\u6b65\u9a5f<\/strong><\/p>\n\n

\u9019\u9805\u7814\u7a76\u7684\u5be6\u969b\u610f\u7fa9\u8d85\u8d8a\u907a\u50b3\u5b78\u3002\u88fd\u85e5\u516c\u53f8\u6b63\u5728\u958b\u767c\u6eab\u548c\u7684\u767c\u708e\u8abf\u7bc0\u7642\u6cd5\uff0c\u53ef\u5728\u4e0d\u6539\u8b8a\u4eba\u985e DNA \u7684\u60c5\u6cc1\u4e0b\u6a21\u64ec\u9019\u7a2e\u5929\u7136\u57fa\u56e0\u8b8a\u9ad4\u7684\u6548\u679c\uff0c\u70ba\u901a\u904e\u85e5\u7269\u5be6\u73fe\u514d\u75ab\u5e73\u8861\u63d0\u4f9b\u4e86\u6f5b\u5728\u9014\u5f91\u3002 <\/strong><\/p>\n\n

\u5be6\u73fe\u514d\u75ab\u5e73\u8861\u7684\u751f\u6d3b\u65b9\u5f0f<\/strong><\/p>\n\n

\u5373\u4f7f\u6c92\u6709\u7f55\u898b\u7684\u9577\u58fd\u8b8a\u9ad4\uff0c\u751f\u6d3b\u65b9\u5f0f\u9078\u64c7\u4e5f\u6709\u52a9\u8907\u88fd\u90e8\u5206\u4fdd\u8b77\u6548\u679c\u3002\u6297\u708e\u98f2\u98df\u6a21\u5f0f\uff0c\u5982 MIND \u6216\u5730\u4e2d\u6d77\u98f2\u98df\uff0c\u5f37\u8abf\u7da0\u8449\u852c\u83dc\u3001\u8393\u679c\u3001\u5805\u679c\u3001\u5168\u7a40\u7269\u548c\u5bcc\u542b\u8102\u80aa\u7684\u9b5a\u985e\uff0c\u540c\u6642\u6e1b\u5c11\u7d05\u8089\u3001\u6cb9\u70b8\u98df\u54c1\u548c\u7cbe\u88fd\u7cd6\u3002\u898f\u5f8b\u7761\u7720\u3001\u58d3\u529b\u7ba1\u7406\u548c\u9069\u5ea6\u9ad4\u529b\u6d3b\u52d5\u4ea6\u6709\u52a9\u964d\u4f4e\u57fa\u7dda\u767c\u708e\u6c34\u5e73\uff0c\u901a\u904e\u4eba\u4eba\u90fd\u80fd\u63a1\u7528\u7684\u65e5\u5e38\u7fd2\u6163\u652f\u6301\u514d\u75ab\u5e73\u8861\u3002 <\/strong><\/p>\n\n

\u5be6\u73fe\u514d\u75ab\u5e73\u8861\u7684\u85e5\u7269\u958b\u767c<\/strong><\/p>\n\n

\u591a\u500b\u7814\u7a76\u5718\u968a\u6b63\u5728\u7814\u7a76\u6eab\u548c\u8abf\u7bc0 cGAS-STING \u901a\u8def\u7684\u5316\u5408\u7269\u3002\u76ee\u6a19\u662f\u5728\u4e0d\u6291\u5236\u611f\u67d3\u9632\u79a6\u6240\u9700\u6025\u6027\u514d\u75ab\u53cd\u61c9\u7684\u60c5\u6cc1\u4e0b\u6e1b\u5c11\u6162\u6027\u767c\u708e\u3002\u5982\u679c\u6210\u529f\uff0c\u9019\u4e9b\u7642\u6cd5\u53ef\u63d0\u4f9b\u4e00\u7a2e\u5065\u5eb7\u8870\u8001\u7684\u85e5\u7406\u5b78\u9014\u5f91\uff0c\u628a\u7f55\u898b\u9577\u58fd\u57fa\u56e0\u7684\u76ca\u8655\u5e36\u7d66\u66f4\u5ee3\u6cdb\u7684\u4eba\u7fa4\u3002 <\/strong><\/p>\n\n

06 \u5c40\u9650\u8207\u672a\u4f86\u65b9\u5411<\/strong><\/p>\n\n

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\u5118\u7ba1\u5b58\u5728\u9019\u4e9b\u6ce8\u610f\u4e8b\u9805\uff0c\u9019\u9805\u7814\u7a76\u63d0\u4f9b\u4e86\u9996\u500b\u6e05\u6670\u8b49\u64da\uff0c\u8868\u660e\u5fae\u8abf\u8eab\u9ad4\u7684\u767c\u708e\u958b\u95dc\u662f\u901a\u5f80\u5065\u5eb7\u8870\u8001\u7684\u6838\u5fc3\u9014\u5f91\u3002\u8981\u9ede\u5f88\u7c21\u55ae\uff1a\u6c7a\u5b9a\u9577\u58fd\u79d1\u5b78\u672a\u4f86\u7684\uff0c\u53ef\u80fd\u662f\u514d\u75ab\u5e73\u8861\uff0c\u800c\u975e\u514d\u75ab\u5f37\u5ea6\u3002 <\/strong><\/p>\n\n

References<\/strong><\/p>\n\n

Putter P C, Guan D, Gehrmann T, et al. Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families[J]. bioRxiv, 2025: 2025.12.04.689698.<\/strong><\/p>\n\n

https:\/\/www.biorxiv.org\/content\/10.64898\/2025.12.04.689698v1<\/strong><\/a><\/p>\n\n

https:\/\/www.cdc.gov\/nchs\/fastats\/life-expectancy.htm<\/a><\/p>\n\n

\u514d\u8cac\u8072\u660e<\/strong><\/p>\n\n

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