{"id":29723,"date":"2026-04-10T09:08:07","date_gmt":"2026-04-10T13:08:07","guid":{"rendered":"https:\/\/www.celfull.com\/%e6%9c%aa%e5%88%86%e9%a1%9e\/nad-metabolism-a-novel-target-for-vascular-health-atherosclerosis-support.html"},"modified":"2026-04-10T09:08:07","modified_gmt":"2026-04-10T13:08:07","slug":"nad-metabolism-a-novel-target-for-vascular-health-atherosclerosis-support","status":"publish","type":"post","link":"https:\/\/www.celfull.com\/zh-hant\/%e6%96%b0%e8%81%9e\/nad-metabolism-a-novel-target-for-vascular-health-atherosclerosis-support.html","title":{"rendered":"NAD \u4ee3\u8b1d\uff1a\u8840\u7ba1\u5065\u5eb7\u8207\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u652f\u6301\u7684\u65b0\u9776\u9ede"},"content":{"rendered":"
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\u65b0 UCLA \u7814\u7a76\u78ba\u8a8d NAD \u4ee3\u8b1d\u70ba\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u8abf\u7bc0\u9776\u9ede<\/h3>\n
\u7531\u52a0\u5dde\u5927\u5b78\u6d1b\u6749\u78ef\u5206\u6821\uff08UCLA\uff09\u91ab\u5b78\u9662\u7684\u8de8\u90e8\u9580\u806f\u5408\u7814\u7a76\u5718\u968a\uff0c\u5728 Arteriosclerosis, Thrombosis, and Vascular Biology \u671f\u520a\u767c\u8868\u4e86\u4e00\u9805\u91cc\u7a0b\u7891\u5f0f\u7814\u7a76\u3002\u901a\u904e\u56b4\u8b39\u7684\u907a\u50b3\u5b78\u5206\u6790\u548c\u9ad4\u5916\u3001\u9ad4\u5167\u6574\u5408\u5be6\u9a57\uff0c\u7814\u7a76\u78ba\u8a8d\u7159\u9170\u80fa N – \u7532\u57fa\u8f49\u79fb\u9176\uff08NNMT\uff09\u57fa\u56e0\u662f\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u7684\u6838\u5fc3\u8abf\u7bc0\u56e0\u5b50\u3002\u7d30\u80de\u4ee3\u8b1d\u5e73\u8861\u901a\u904e\u8abf\u7bc0\u5de8\u566c\u7d30\u80de\u589e\u6b96\u548c\u51cb\u4ea1\uff0c\u4e3b\u5c0e\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u75c5\u8b8a\u7684\u767c\u5c55\u3002\u9019\u9805\u958b\u5275\u6027\u767c\u73fe\u586b\u88dc\u4e86\u7d30\u80de\u4ee3\u8b1d\u8abf\u7bc0\u8207\u5fc3\u8840\u7ba1\u5065\u5eb7\u4e4b\u9593\u7684\u7814\u7a76\u7a7a\u767d\uff0c\u70ba\u8840\u7ba1\u4fdd\u8b77\u63d0\u4f9b\u4e86\u65b0\u7684\u79d1\u5b78\u8b49\u64da\u548c\u9776\u5411\u5e72\u9810\u65b9\u5411\u3002 <\/div>\n
\u4f5c\u70ba\u591a\u7a2e\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u4e3b\u8981\u75c5\u7406\u57fa\u790e\uff0c\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u7684\u7279\u5fb5\u662f\u5de8\u566c\u7d30\u80de\u7570\u5e38\u7d2f\u7a4d\u3001\u8840\u7ba1\u58c1\u7d30\u80de\u904e\u5ea6\u589e\u6b96\u548c\u6ce1\u6cab\u7d30\u80de\u5f62\u6210\u3002\u6578\u5341\u5e74\u4f86\uff0c\u5c0b\u627e\u6291\u5236\u9019\u4e00\u75c5\u7406\u904e\u7a0b\u7684\u95dc\u9375\u5206\u5b50\u9776\u9ede\u4e00\u76f4\u662f\u5fc3\u8840\u7ba1\u7814\u7a76\u7684\u6838\u5fc3\u7126\u9ede\uff0c\u800c\u65b0\u63ed\u793a\u7684 NAD \u4ee3\u8b1d\u8abf\u7bc0\u8ef8\u586b\u88dc\u4e86\u9019\u4e00\u9818\u57df\u7684\u91cd\u8981\u6280\u8853\u7a7a\u767d\u3002 <\/div>\n

NNMT \u9176\u7684\u6838\u5fc3\u529f\u80fd\uff1aNAD \u4ee3\u8b1d\u7684\u95dc\u9375\u8abf\u7bc0\u56e0\u5b50<\/h3>\n
\u4f5c\u70ba\u91cd\u8981\u7684\u7d30\u80de\u5167\u8f14\u9176\uff0cNAD \u53c3\u8207\u80fd\u91cf\u4ee3\u8b1d\u548c\u6c27\u5316\u9084\u539f\u5e73\u8861\u7b49\u591a\u9805\u751f\u7406\u6d3b\u52d5\u3002\u7136\u800c\uff0c\u5b83\u5728\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u4e2d\u7684\u5177\u9ad4\u8abf\u7bc0\u6a5f\u5236\u9577\u671f\u4e0d\u660e\u3002\u5229\u7528\u5c0f\u9f20\u6a21\u578b\u7684\u57fa\u56e0\u7d44\u95dc\u806f\u5206\u6790\uff08GWAS\uff09\uff0cUCLA \u7814\u7a76\u5718\u968a\u6210\u529f\u628a NNMT \u57fa\u56e0\u5b9a\u4f4d\u65bc 9 \u865f\u67d3\u8272\u9ad4\uff0c\u9a57\u8b49\u4e86\u5b83\u8207\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u75c5\u8b8a\u7684\u5f37\u70c8\u76f8\u95dc\u6027\uff0c\u53ca\u5176\u5c0d NAD \u4ee3\u8b1d\u7684\u6c7a\u5b9a\u6027\u8abf\u7bc0\u4f5c\u7528\u3002 <\/div>\n
\u7159\u9170\u80fa N – \u7532\u57fa\u8f49\u79fb\u9176\uff08NNMT\uff09\u662f\u5ee3\u6cdb\u5206\u4f48\u65bc\u4eba\u9ad4\u7d44\u7e54\u7684\u4ee3\u8b1d\u9176\u3002\u5176\u6838\u5fc3\u529f\u80fd\u662f\u4ee5 S – \u817a\u82f7\u7532\u786b\u6c28\u9178\uff08SAM\uff09\u70ba\u7532\u57fa\u4f9b\u9ad4\uff0c\u50ac\u5316 NAD \u5408\u6210\u5fc5\u9700\u524d\u9ad4\u7159\u9170\u80fa\u7684\u7532\u57fa\u5316\uff0c\u8f49\u5316\u70ba N – \u7532\u57fa\u7159\u9170\u80fa\uff08MNAM\uff09\u3002\u9019\u4e00\u904e\u7a0b\u76f4\u63a5\u8abf\u7bc0\u7d30\u80de\u5167\u8f14\u9176\u6c34\u5e73\u7684\u88dc\u6551\u5408\u6210\u9014\u5f91\u548c\u52d5\u614b\u5e73\u8861\u3002NNMT \u6700\u521d\u88ab\u5b9a\u7fa9\u70ba\u7159\u9170\u80fa\u6e05\u9664\u9176\uff0c\u73fe\u5df2\u8b49\u5be6\u53c3\u8207\u591a\u689d\u4ee3\u8b1d\u9014\u5f91\u3002\u5b83\u5728\u809d\u81df\u3001\u8102\u80aa\u7d44\u7e54\u548c\u5de8\u566c\u7d30\u80de\u4e2d\u9ad8\u5ea6\u8868\u9054\uff0c\u662f\u63a7\u5236\u8840\u7ba1\u75c5\u8b8a\u9032\u5c55\u7684\u6838\u5fc3\u4e0a\u6e38\u57fa\u56e0\u3002 <\/div>\n

\u5c0f\u9f20\u6a21\u578b\u5be6\u9a57\u9a57\u8b49 NNMT-NAD \u4ee3\u8b1d\u8abf\u7bc0\u8ef8<\/h3>\n
\u7814\u7a76\u5718\u968a\u63a1\u7528\u4e86\u56b4\u8b39\u7684\u4e09\u968e\u6bb5\u5be6\u9a57\u6846\u67b6\uff1a\u57fa\u56e0\u5b9a\u4f4d\u3001\u529f\u80fd\u9a57\u8b49\u548c\u6a5f\u5236\u5206\u6790\u3002\u57fa\u65bc\u5c0d\u8d85\u904e 100 \u500b\u8fd1\u4ea4\u5c0f\u9f20\u54c1\u7cfb\u7684\u6df7\u5408\u5c0f\u9f20\u591a\u6a23\u6027\u5c0f\u7d44\uff08HMDP\uff09GWAS \u5206\u6790\uff0c\u7814\u7a76\u4eba\u54e1\u8b49\u5be6 NNMT \u57fa\u56e0\u8868\u9054\u6c34\u5e73\u8207\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u75c5\u8b8a\u9762\u7a4d\u9ad8\u5ea6\u6b63\u76f8\u95dc\uff0c\u8b49\u660e\u5176\u8207\u8840\u7ba1\u75c5\u8b8a\u7684\u56e0\u679c\u95dc\u4fc2\u3002 <\/div>\n
\u5728\u96a8\u5f8c\u5c0d\u9ad8\u8102\u8840\u75c7 APOE-Leiden.CETP \u8f49\u57fa\u56e0\u5c0f\u9f20\u7684\u529f\u80fd\u9a57\u8b49\u5be6\u9a57\u4e2d\uff0c\u7cfb\u7d71\u6027\u6291\u5236 NNMT \u53d6\u5f97\u4e86\u986f\u8457\u7684\u8840\u7ba1\u4fdd\u8b77\u6548\u679c\uff1a\u96cc\u6027\u5c0f\u9f20\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u75c5\u8b8a\u9762\u7a4d\u6e1b\u5c11 10 \u500d\uff0c\u96c4\u6027\u5c0f\u9f20\u6e1b\u5c11 5 \u500d\u3002\u8207\u6b64\u540c\u6642\uff0c\u8840\u6f3f\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08LDL\uff09\u548c\u6975\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08VLDL\uff09\u81bd\u56fa\u9187\u6c34\u5e73\u986f\u8457\u4e0b\u964d\uff0c\u76f4\u63a5\u8b49\u5be6 NNMT \u901a\u904e\u64fe\u4e82\u7d30\u80de\u5167\u4ee3\u8b1d\u7a69\u614b\u4ecb\u5c0e\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u9032\u5c55\u3002 <\/div>\n
\u7d44\u7e54\u7279\u7570\u6027\u6572\u4f4e\u5be6\u9a57\u9032\u4e00\u6b65\u91d0\u6e05\u4e86\u9019\u4e00\u6a5f\u5236\u7684\u6838\u5fc3\u4f5c\u7528\u90e8\u4f4d\u3002\u5118\u7ba1 NNMT \u5728\u809d\u81df\u548c\u8102\u80aa\u7d44\u7e54\u4e2d\u9ad8\u5ea6\u8868\u9054\uff0c\u4f46\u5728\u9019\u4e9b\u7d44\u7e54\u4e2d\u91dd\u5c0d\u6027\u6291\u5236 NNMT \u672a\u80fd\u6539\u5584\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u75c5\u8b8a\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u9aa8\u9ad3\u79fb\u690d\u5be6\u9a57\u7d66\u51fa\u4e86\u6c7a\u5b9a\u6027\u7d50\u679c\uff1a\u79fb\u690d NNMT \u6572\u9664\u5c0f\u9f20\u7684\u9aa8\u9ad3\u4f7f\u75c5\u8b8a\u9762\u7a4d\u6e1b\u5c11 50%\uff0c\u986f\u8457\u6291\u5236\u5de8\u566c\u7d30\u80de\u589e\u6b96\uff0c\u4e26\u4fc3\u9032\u75c5\u8b8a\u90e8\u4f4d\u7684\u5de8\u566c\u7d30\u80de\u51cb\u4ea1\u3002 <\/div>\n
\u91dd\u5c0d\u95dc\u9375 NAD \u7cd6\u6c34\u89e3\u9176 CD38 \u7684\u88dc\u5145\u5be6\u9a57\u9032\u4e00\u6b65\u9a57\u8b49\u4e86\u7d30\u80de\u4ee3\u8b1d\u5e73\u8861\u7684\u6838\u5fc3\u5730\u4f4d\u3002CD38 \u6572\u9664\u540c\u6a23\u80fd\u6709\u6548\u7d13\u7de9\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u3002\u5f9e\u6a5f\u5236\u4e0a\u8b1b\uff0cNNMT \u6572\u9664\u6e1b\u5c11\u7159\u9170\u80fa\u7532\u57fa\u5316\uff0c\u70ba NAD \u88dc\u6551\u5408\u6210\u4fdd\u7559\u66f4\u591a\u524d\u9ad4\uff1bCD38 \u6572\u9664\u5247\u6e1b\u5c11 NAD \u964d\u89e3\u3002\u5169\u7a2e\u5e72\u9810\u90fd\u80fd\u63d0\u9ad8\u7d30\u80de\u5167 NAD \u53ef\u7528\u6027\uff0c\u5171\u540c\u8b49\u5be6\u5e73\u8861\u7684\u8f14\u9176\u4ee3\u8b1d\u662f\u6291\u5236\u8840\u7ba1\u75c5\u8b8a\u7684\u95dc\u9375\u3002 <\/div>\n

\u5206\u5b50\u6a5f\u5236\uff1aNAD \u4ee3\u8b1d\u5982\u4f55\u8abf\u7bc0\u5de8\u566c\u7d30\u80de\u8207\u8840\u7ba1\u5065\u5eb7<\/h3>\n
\u9ad4\u5916\u7d30\u80de\u5be6\u9a57\u9032\u4e00\u6b65\u63ed\u793a\u4e86 NNMT – \u4ee3\u8b1d – \u5de8\u566c\u7d30\u80de\u8abf\u7bc0\u8ef8\u80cc\u5f8c\u7684\u5206\u5b50\u908f\u8f2f\u3002\u4f86\u81ea NNMT \u96dc\u5408\u6572\u9664\u5c0f\u9f20\u7684\u9aa8\u9ad3\u4f86\u6e90\u5de8\u566c\u7d30\u80de\uff0c\u5176 NAD\/NADH \u6bd4\u503c\u6bd4\u91ce\u751f\u578b\u5c0f\u9f20\u9ad8\u51fa\u8d85\u904e 50%\u3002\u5347\u9ad8\u7684\u8f14\u9176\u5e73\u8861\u4f7f\u5de8\u566c\u7d30\u80de\u589e\u6b96\u7387\u964d\u4f4e 50%\uff0c\u4e26\u986f\u8457\u589e\u5f37\u7d30\u80de\u51cb\u4ea1\u3002\u901a\u904e siRNA \u5e72\u9810\u6291\u5236 NNMT \u8868\u9054\u5f8c\uff0c\u89c0\u5bdf\u5230\u4e00\u81f4\u7684\u7d50\u679c\u3002 <\/div>\n
\u5177\u9ad4\u800c\u8a00\uff0cNNMT \u6d88\u8017 NAD \u5408\u6210\u524d\u9ad4\u4ee5\u963b\u65b7\u7d30\u80de\u5167 NAD \u88dc\u6551\u5408\u6210\uff0c\u964d\u4f4e NAD \u6c34\u5e73\uff0c\u89f8\u767c\u5de8\u566c\u7d30\u80de\u904e\u5ea6\u589e\u6b96\u548c\u75c5\u8b8a\u7d2f\u7a4d\u3002\u7576 NNMT \u88ab\u6291\u5236\u6642\uff0c\u672a\u88ab\u6d88\u8017\u7684\u7159\u9170\u80fa\u5145\u5206\u53c3\u8207 NAD \u5408\u6210\uff0c\u63d0\u9ad8\u7d30\u80de\u5167 NAD \u6c34\u5e73\uff0c\u6291\u5236\u5de8\u566c\u7d30\u80de\u904e\u5ea6\u751f\u9577\u3001\u4fc3\u9032\u75c5\u7406\u6027\u7d30\u80de\u51cb\u4ea1\uff0c\u6700\u7d42\u6e1b\u5c11\u8840\u7ba1\u58c1\u4e0a\u7684\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u75c5\u8b8a\u6c89\u7a4d\u3002 <\/div>\n
\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u55ae\u7368\u5e72\u9810 NAD \u4ee3\u8b1d\u7269\u7121\u6cd5\u8907\u88fd NNMT \u6291\u5236\u7684\u6297\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u6548\u679c\u3002\u6b64\u5916\uff0cNNMT \u8abf\u7bc0\u7684\u964d\u8102\u6548\u679c\u50c5\u4f54\u5176\u8840\u7ba1\u4fdd\u8b77\u76ca\u8655\u7684 30%\u3002\u9019\u8b49\u660e NNMT \u6539\u5584\u52d5\u8108\u7ca5\u6a23\u786c\u5316\uff0c\u4e26\u975e\u901a\u904e\u8abf\u7bc0\u5168\u8eab\u8840\u8102\u6216\u5faa\u74b0 NAD \u4ee3\u8b1d\u7269\uff0c\u800c\u662f\u901a\u904e\u5c40\u90e8\u8abf\u7bc0\u75c5\u8b8a\u5de8\u566c\u7d30\u80de\u7684\u7d30\u80de\u4ee3\u8b1d\u4f86\u9006\u8f49\u75c5\u7406\u8b8a\u5316\u3002 <\/div>\n

NAD \u4ee3\u8b1d\u9776\u9ede\u7684\u81e8\u5e8a\u8207\u5065\u5eb7\u61c9\u7528\u524d\u666f<\/h3>\n
\u9019\u9805\u958b\u5275\u6027\u7814\u7a76\u64f4\u5c55\u4e86\u8f14\u9176\u4ee3\u8b1d\u7814\u7a76\u7684\u61c9\u7528\u908a\u754c\uff0c\u70ba\u8840\u7ba1\u5065\u5eb7\u7dad\u8b77\u548c\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u5e72\u9810\u5e36\u4f86\u591a\u500b\u5275\u65b0\u65b9\u5411\u3002\u5728\u9776\u5411\u6cbb\u7642\u65b9\u9762\uff0c\u5de8\u566c\u7d30\u80de\u7279\u7570\u6027 NNMT \u6291\u5236\u5291\u4ee3\u8868\u65b0\u4e00\u4ee3\u8840\u7ba1\u4fdd\u8b77\u7b56\u7565\u3002\u8207\u50b3\u7d71\u964d\u8102\u65b9\u6cd5\u4e0d\u540c\uff0c\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u6838\u5fc3\u75c5\u7406\u6027\u5de8\u566c\u7d30\u80de\uff0c\u901a\u904e\u8abf\u7bc0\u5c40\u90e8\u7d30\u80de\u4ee3\u8b1d\u5e73\u8861\u5f9e\u6839\u6e90\u963b\u65b7\u75c5\u8b8a\u9032\u5c55\uff0c\u70ba\u5c0d\u5e38\u898f\u5e72\u9810\u53cd\u61c9\u4e0d\u4f73\u7684\u4eba\u7fa4\u63d0\u4f9b\u4e86\u66ff\u4ee3\u65b9\u6848\u3002 <\/div>\n
\u4f5c\u70ba\u7d93\u5178\u7684 NAD \u964d\u89e3\u9176\uff0cCD38 \u6291\u5236\u5291\u5df2\u5728\u4ee3\u8b1d\u8abf\u7bc0\u9818\u57df\u88ab\u5ee3\u6cdb\u7814\u7a76\u3002\u9019\u9805\u7814\u7a76\u70ba\u5b83\u5011\u5728\u8840\u7ba1\u5065\u5eb7\u9818\u57df\u7684\u64f4\u5c55\u61c9\u7528\u63d0\u4f9b\u4e86\u5805\u5be6\u7684\u79d1\u5b78\u652f\u6301\u3002\u672a\u4f86\uff0c\u91dd\u5c0d\u6574\u500b NAD \u4ee3\u8b1d\u9014\u5f91\u7684\u806f\u5408\u5e72\u9810\u7b56\u7565\uff0c\u6709\u671b\u5be6\u73fe\u66f4\u5168\u9762\u7684\u8840\u7ba1\u4fdd\u8b77\u6548\u679c\u3002 <\/div>\n
\u5728\u5065\u5eb7\u98a8\u96aa\u9810\u6e2c\u65b9\u9762\uff0cNNMT \u57fa\u56e0\u7684\u55ae\u6838\u82f7\u9178\u591a\u614b\u6027\uff08SNP\uff09\u5982 rs33700043\uff0c\u53ef\u4ee5\u89e3\u91cb NNMT \u8868\u9054\u500b\u9ad4\u5dee\u7570\u7684 30% \u81f3 70%\u3002\u7d50\u5408\u8840\u6f3f NAD \u4ee3\u8b1d\u7269\u6aa2\u6e2c\uff0c\u9019\u4e9b\u907a\u50b3\u6a19\u8a18\u53ef\u88ab\u958b\u767c\u70ba\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u98a8\u96aa\u8a55\u4f30\u7684\u751f\u7269\u6a19\u8a8c\u7269\uff0c\u57fa\u65bc\u7d30\u80de\u4ee3\u8b1d\u72c0\u614b\u5be6\u73fe\u5fc3\u8840\u7ba1\u98a8\u96aa\u7684\u7cbe\u6e96\u9810\u8b66\u548c\u9776\u5411\u9810\u9632\u3002<\/div>\n
\u6b64\u5916\uff0c\u65b0\u767c\u73fe\u7684\u4ee3\u8b1d – \u5de8\u566c\u7d30\u80de\u8abf\u7bc0\u8ef8\uff0c\u70ba\u7cd6\u5c3f\u75c5\u8840\u7ba1\u75c5\u8b8a\u548c\u985e\u98a8\u6fd5\u95dc\u7bc0\u708e\u7b49\u767c\u708e\u76f8\u95dc\u4f75\u767c\u75c7\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u5bf6\u8cb4\u53c3\u8003\uff0c\u63a8\u52d5 NAD \u4ee3\u8b1d\u9776\u9ede\u5728\u591a\u91cd\u7cfb\u7d71\u5065\u5eb7\u7ba1\u7406\u4e2d\u7684\u5ee3\u6cdb\u61c9\u7528\u3002<\/div>\n

NAD \u4ee3\u8b1d\u5e72\u9810\u7684\u7814\u7a76\u5c40\u9650\u8207\u672a\u4f86\u767c\u5c55<\/h3>\n
\u5118\u7ba1\u524d\u666f\u5ee3\u95ca\uff0cNAD \u4ee3\u8b1d\u8abf\u7bc0\u548c NNMT \u9776\u5411\u5e72\u9810\u7684\u8f49\u5316\u61c9\u7528\u4ecd\u9700\u9032\u4e00\u6b65\u6df1\u5165\u7814\u7a76\u3002\u76ee\u524d\u7684\u5be6\u9a57\u7d50\u8ad6\u4e3b\u8981\u57fa\u65bc\u5c0f\u9f20\u6a21\u578b\uff0c\u4eba\u985e\u81e8\u5e8a\u5b89\u5168\u6027\u548c\u529f\u6548\u6578\u64da\u4ecd\u6709\u5f85\u88dc\u5145\u548c\u9a57\u8b49\u3002 <\/div>\n
\u6b64\u5916\uff0c\u5de8\u566c\u7d30\u80de NAD \u4ee3\u8b1d\u8abf\u7bc0\u7d30\u80de\u589e\u6b96\u548c\u51cb\u4ea1\u7684\u4e0b\u6e38\u5206\u5b50\u6a5f\u5236\u5c1a\u672a\u5b8c\u5168\u95e1\u660e\u3002NAD \u6c34\u5e73\u8207 Akt \u9014\u5f91\u3001SIRT1-FOXO3 \u8ef8\u7b49\u95dc\u9375\u4fe1\u865f\u901a\u8def\u4e4b\u9593\u7684\u76f8\u4e92\u4f5c\u7528\u4ecd\u9700\u7cfb\u7d71\u63a2\u7d22\u3002\u5728\u6280\u8853\u4e0a\uff0c\u5be6\u73fe NNMT \u6291\u5236\u5291\u5c0d\u5de8\u566c\u7d30\u80de\u7684\u7cbe\u6e96\u9776\u5411\u905e\u9001\uff0c\u540c\u6642\u907f\u514d\u5c0d\u809d\u81df\u548c\u8102\u80aa\u7d44\u7e54\u7684\u4e0d\u826f\u5f71\u97ff\uff0c\u4e5f\u662f\u81e8\u5e8a\u8f49\u5316\u9700\u8981\u89e3\u6c7a\u7684\u95dc\u9375\u6311\u6230\u3002 <\/div>\n

\u7d50\u8ad6<\/h3>\n
\u9019\u9805 UCLA \u7814\u7a76\u9996\u6b21\u7cfb\u7d71\u95e1\u660e\u4e86 NNMT-NAD \u4ee3\u8b1d – \u5de8\u566c\u7d30\u80de\u8ef8\u5728\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u4e2d\u7684\u6838\u5fc3\u8abf\u7bc0\u4f5c\u7528\uff0c\u70ba\u5fc3\u8840\u7ba1\u75c5\u7406\u6a5f\u5236\u548c\u8840\u7ba1\u5065\u5eb7\u5e72\u9810\u958b\u95e2\u4e86\u65b0\u8996\u89d2\u3002\u96a8\u8457\u5c0d NAD \u4ee3\u8b1d\u8abf\u7bc0\u7db2\u7d61\u7684\u6301\u7e8c\u6df1\u5165\u7814\u7a76\u548c\u9776\u5411\u5e72\u9810\u6280\u8853\u7684\u8fed\u4ee3\uff0cNAD \u4ee3\u8b1d\u9014\u5f91\u6709\u671b\u6210\u70ba\u9810\u9632\u548c\u6539\u5584\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u7684\u65b0\u6838\u5fc3\u9632\u7dda\uff0c\u70ba\u7cbe\u6e96\u5fc3\u8840\u7ba1\u5065\u5eb7\u7ba1\u7406\u5e36\u4f86\u5275\u65b0\u7a81\u7834\u3002 <\/div>\n

References<\/h2>\n
Sinha S K, Swichkow C R, Farahi L, et al. NAD metabolism regulates proliferation of macrophages in atherosclerosis[J]. Arteriosclerosis, thrombosis, and vascular biology, 2025, 45(11): 1997-2014. <\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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