{"id":29743,"date":"2026-09-24T23:15:00","date_gmt":"2026-09-25T03:15:00","guid":{"rendered":"https:\/\/www.celfull.com\/?p=29743"},"modified":"2026-10-16T04:02:55","modified_gmt":"2026-10-16T08:02:55","slug":"premature-aging-inside-the-nad-trials-for-people-whose-clock-runs-fast","status":"publish","type":"post","link":"https:\/\/www.celfull.com\/zh-hant\/%e6%96%b0%e8%81%9e\/premature-aging-inside-the-nad-trials-for-people-whose-clock-runs-fast.html","title":{"rendered":"\u63d0\u65e9\u8870\u8001\uff1a\u8d70\u9032 NAD+ \u81e8\u5e8a\u8a66\u9a57\u7684\u5167\u90e8 \u2014\u2014 \u70ba\u90a3\u4e9b\u751f\u7406\u6642\u9418\u8d70\u5f97\u5feb\u7684\u4eba"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>\u63d0\u65e9\u8870\u8001\u75be\u75c5\u662f NAD+ \u7814\u7a76\u8fc4\u4eca\u7522\u751f\u6700\u5177\u9ad4\u4eba\u985e\u6210\u679c\u7684\u9818\u57df\u3002NAD+ \u662f\u7d30\u80de\u80fd\u91cf\u4ee3\u8b1d\u6838\u5fc3\u7684\u8f14\u9176\uff0c\u6578\u767e\u7bc7\u8ad6\u6587\u63cf\u8ff0\u4e86\u5b83\u5982\u4f55\u53c3\u8207 DNA \u4fee\u5fa9\u3001\u57fa\u56e0\u7d44\u7a69\u5b9a\u6027\u3001\u6c27\u5316\u9084\u539f\u5e73\u8861\u3001\u7c92\u7dda\u9ad4\u5065\u5eb7\u548c\u7aef\u7c92\u7dad\u8b77\uff08Bohr, 2026\uff09\u3002\u9019\u4e9b\u5de5\u4f5c\u5927\u90e8\u5206\u5728\u52d5\u7269\u6216\u7d30\u80de\u4e2d\u5b8c\u6210\u3002\u66f4\u96e3\u7684\u554f\u984c\u662f\u5b83\u5c0d\u4eba\u610f\u5473\u8457\u751a\u9ebc\uff0c\u800c\u6700\u5c16\u92b3\u7684\u63d0\u554f\u65b9\u5f0f\uff0c\u662f\u89c0\u5bdf\u90a3\u4e9b\u8eab\u9ad4\u8870\u8001\u901f\u5ea6\u9060\u6bd4\u51fa\u751f\u65e5\u671f\u6240\u986f\u793a\u66f4\u5feb\u7684\u75c5\u4eba\u3002   <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c 01 \u90e8\u5206\uff1a\u63d0\u65e9\u8870\u8001\u7814\u7a76\u5f9e NAD+ \u958b\u59cb<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u6a5f\u5236\u672c\u8eab\u4e26\u7121\u722d\u8b70\u3002NAD+ \u662f\u53bb\u4e59\u91af\u5316\u9176\uff08sirtuin\uff09\u548c PARP \u9176\u5bb6\u65cf\u7684\u53d7\u8cea\uff0c\u9019\u4e9b\u9176\u8ca0\u8cac\u61c9\u6fc0\u53cd\u61c9\u3001\u708e\u75c7\u63a7\u5236\u548c DNA \u4fee\u5fa9\uff0c\u540c\u6642 NAD+ \u4e5f\u662f\u7522\u751f ATP \u7684\u96fb\u5b50\u50b3\u905e\u93c8\u6240\u5fc5\u9700\u7684\u3002\u52d5\u7269\u6a21\u578b\u53cd\u8986\u986f\u793a\uff0c\u63d0\u9ad8 NAD+ \u53ef\u7528\u6027\u6703\u6539\u8b8a\u4ee3\u8b1d\u548c\u7d44\u7e54\u529f\u80fd\u3002\u8981\u628a\u9019\u8f49\u5316\u70ba\u4e00\u822c\u6297\u8870\u8001\u5efa\u8b70\u4e26\u4e0d\u5bb9\u6613\uff0c\u56e0\u70ba\u5065\u5eb7\u6210\u5e74\u4eba\u7684\u8d77\u9ede\u5dee\u7570\u5f88\u5927\u3001\u7d42\u9ede\u6307\u6a19\u79fb\u52d5\u7de9\u6162\uff0c\u800c\u4e14\u4efb\u4f55\u6548\u679c\u90fd\u5f88\u96e3\u8207\u751f\u6d3b\u65b9\u5f0f\u5340\u5206\u958b\u4f86\u3002   <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u63d0\u65e9\u8870\u8001\u75be\u75c5\u60a3\u8005\u4ee4\u6e2c\u91cf\u8b8a\u5f97\u66f4\u5bb9\u6613\u3002\u4ed6\u5011\u7684\u8870\u9000\u662f\u52a0\u901f\u7684\u3001\u53ef\u6e2c\u91cf\u7684\u3001\u6709\u8a18\u9304\u7684\uff0c\u800c\u4e14\u75c7\u72c0\u51fa\u73fe\u5f97\u8db3\u5920\u65e9\uff0c\u4f7f\u8a66\u9a57\u80fd\u5728\u73fe\u5be6\u6642\u9593\u6846\u67b6\u5167\u8ddf\u9032\u4ed6\u5011\u3002\u7576\u9019\u500b\u7fa4\u9ad4\u51fa\u73fe\u8b8a\u5316\u6642\uff0c\u8a0a\u865f\u6bd4\u540c\u6a23\u898f\u6a21\u7684\u5065\u5eb7\u4eba\u7fa4\u66f4\u5bb9\u6613\u8b80\u53d6\u3002  <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u6709\u4e00\u9ede\u9700\u8981\u6ce8\u610f\u653e\u5728\u958b\u982d\u3002\u7f55\u898b\u63d0\u65e9\u8870\u8001\u75be\u75c5\u7684\u7d50\u679c\uff0c\u4e26\u4e0d\u80fd\u8f49\u79fb\u5230\u6b63\u5728\u9078\u8cfc\u9577\u58fd\u88dc\u5145\u54c1\u7684\u5065\u5eb7\u6210\u5e74\u4eba\u8eab\u4e0a\u3002\u4eba\u7fa4\u3001\u751f\u7269\u5b78\u548c\u7d42\u9ede\u6307\u6a19\u90fd\u4e0d\u540c\uff0c\u800c\u4e14\u4e0b\u6587\u63cf\u8ff0\u7684\u8a66\u9a57\u662f\u70ba\u6e2c\u8a66\u5b89\u5168\u6027\u548c\u8207\u75be\u75c5\u76f8\u95dc\u7684\u6307\u6a19\u800c\u8a2d\u8a08\uff0c\u4e26\u975e\u4e00\u822c\u6297\u8870\u8001\u6548\u679c\u3002  <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c 02 \u90e8\u5206\uff1a\u70ba\u751a\u9ebc\u8840\u6db2 NAD+ \u4e0d\u80fd\u9810\u6e2c\u63d0\u65e9\u8870\u8001<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u9577\u58fd\u6587\u737b\u4e2d\u88ab\u91cd\u8907\u6700\u591a\u7684\u8aaa\u6cd5\u662f NAD+ \u96a8\u5e74\u9f61\u4e0b\u964d\u3002\u5be6\u6e2c\u6578\u64da\u6bd4\u9019\u53e5\u8a71\u6240\u6697\u793a\u7684\u66f4\u53c3\u5dee\u3002Yang \u53ca\u5176\u540c\u4e8b\u6e2c\u91cf\u4e86 1,518 \u540d 18 \u6b72\u53ca\u4ee5\u4e0a\u6210\u5e74\u4eba\u7684\u5168\u8840 NAD+\u3002\u7537\u6027\u5e73\u5747 34.5 \u5fae\u6469\u723e\uff0f\u5347\uff0c\u5973\u6027 31.3\u3002\u4e0b\u964d\u8da8\u52e2\u5728 50 \u6b72\u524d\u51fa\u73fe\uff0c\u5728 40 \u81f3 49 \u6b72\u7d44\u9054\u5230\u986f\u8457\uff0c\u7136\u5f8c\u6d88\u5931\u3002\u5728\u7537\u6027\u4e2d\uff0c60 \u6b72\u53ca\u4ee5\u4e0a\u7d44\u986f\u8457\u4f4e\u65bc 29 \u6b72\u4ee5\u4e0b\u7d44\u3002\u5728\u5973\u6027\u4e2d\uff0c\u4e94\u500b\u5e74\u9f61\u7d44\u4e4b\u9593\u6c92\u6709\u51fa\u73fe\u986f\u8457\u5dee\u7570\uff08Yang et al., 2022\uff09\u3002      <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u540c\u4e00\u7814\u7a76\u5831\u544a\u6307\u51fa\uff0c\u540c\u9f61\u4eba\u4e4b\u9593\u5b58\u5728\u5f88\u5927\u5dee\u7570\uff0c\u90e8\u5206\u53c3\u8207\u8005\u9060\u9ad8\u65bc\u5176\u6240\u5c6c\u7d44\u5225\u7684\u5e73\u5747\u6c34\u5e73\u3002\u6a23\u672c\u91cf\u3001\u6e2c\u91cf\u65b9\u6cd5\u548c\u7d44\u7e54\u4e4b\u9593\u7684\u5dee\u7570\uff0c\u90fd\u662f\u89e3\u91cb\u9019\u7a2e\u53c3\u5dee\u5716\u666f\u7684\u5408\u7406\u539f\u56e0\u3002\u7121\u8ad6\u539f\u56e0\u662f\u751a\u9ebc\uff0c\u5be6\u969b\u8981\u9ede\u4ecd\u7136\u6210\u7acb\uff1a\u5e74\u9f61\u7121\u6cd5\u5f88\u597d\u5730\u9810\u6e2c\u8ab0\u7f3a\u4e4f NAD+\uff0c\u800c\u6c34\u5e73\u63a5\u8fd1\u540c\u9f61\u5e73\u5747\u503c\u7684\u4eba\uff0c\u5c0d\u88dc\u5145\u5291\u7684\u53cd\u61c9\u7a7a\u9593\u6709\u9650\u3002  <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u9019\u7a2e\u53ef\u8b8a\u6027\u6b63\u662f\u63d0\u65e9\u8870\u8001\u75be\u75c5\u7814\u7a76\u7d93\u5e38\u88ab\u5f15\u7528\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u5728 DNA \u4fee\u5fa9\u5b58\u5728\u5df2\u77e5\u7f3a\u9677\u7684\u75c5\u4eba\u8eab\u4e0a\uff0c\u8017\u7aed\u80cc\u5f8c\u6709\u8a18\u9304\u7684\u6a5f\u5236\uff0c\u800c\u975e\u7d71\u8a08\u8da8\u52e2\uff0c\u9019\u5c0d\u81e8\u5e8a\u8a66\u9a57\u4f86\u8aaa\u662f\u5f37\u5f97\u591a\u7684\u8d77\u9ede\u3002 <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c 03 \u90e8\u5206\uff1a\u628a\u63d0\u65e9\u8870\u8001\u8b8a\u6210\u8a3a\u65b7\u7684\u7f55\u898b\u75be\u75c5<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u5982\u679c\u5b58\u5728\u6297\u8870\u8001\u85e5\u7269\uff0c\u6700\u9700\u8981\u5b83\u7684\u4eba\u4e0d\u6703\u662f\u516d\u5341\u591a\u6b72\u7684\u5065\u5eb7\u6210\u5e74\u4eba\uff0c\u800c\u662f\u90a3\u4e9b\u8870\u9000\u5f9e\u7ae5\u5e74\u6216\u9752\u6625\u671f\u5c31\u958b\u59cb\u7684\u75c5\u4eba\u3002\u56db\u7a2e\u75be\u75c5\u7d44\u6210\u6700\u70ba\u4eba\u6240\u77e5\u7684\u7fa4\u7d44\u3002  <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u56db\u7a2e\u6700\u70ba\u4eba\u719f\u77e5\u7684\u63d0\u65e9\u8870\u8001\u75be\u75c5<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6c83\u7d0d\u7d9c\u5408\u75c7\uff08WS\uff09\u3002\u7531\u640d\u5bb3 DNA \u96d9\u93c8\u65b7\u88c2\u4fee\u5fa9\u7684 WRN \u57fa\u56e0\u7a81\u8b8a\u5f15\u8d77\u3002\u5fb5\u72c0\u5728\u5341\u5e7e\u6b72\u6216\u66f4\u665a\u51fa\u73fe\uff0c\u5305\u62ec\u767d\u9aee\u3001\u808c\u8089\u840e\u7e2e\u548c\u7cd6\u5c3f\u75c5\uff0c\u8a31\u591a\u75c5\u4eba\u6d3b\u4e0d\u904e 60 \u6b72\u3002NAD+ \u504f\u4f4e\uff0c\u7c92\u7dda\u9ad4\u81ea\u566c\u6709\u7f3a\u9677\u3002   <\/strong><\/li>\n\n\n\n<li><strong>\u79d1\u51f1\u6069\u7d9c\u5408\u75c7\uff08CS\uff09\u3002\u7531\u5f71\u97ff\u8f49\u9304\u5076\u806f\u6838\u82f7\u9178\u5207\u9664\u4fee\u5fa9\u7684 CSA \u6216 CSB \u7a81\u8b8a\u5f15\u8d77\u3002\u751f\u9577\u9072\u7de9\u3001\u795e\u7d93\u9000\u5316\u3001\u5c0d\u5149\u654f\u611f\u548c\u63d0\u65e9\u8870\u8001\u5728\u751f\u547d\u65e9\u671f\u51fa\u73fe\u3002  <\/strong><\/li>\n\n\n\n<li><strong>\u5171\u6fdf\u5931\u8abf &#8211; \u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u75c7\uff08AT\uff09\u3002\u7531\u64fe\u4e82\u96d9\u93c8\u65b7\u88c2\u4fee\u5fa9\u8abf\u63a7\u7684 ATM \u7a81\u8b8a\u5f15\u8d77\u3002\u5c0f\u8166\u6027\u5171\u6fdf\u5931\u8abf\u3001\u795e\u7d93\u9000\u5316\u3001\u514d\u75ab\u7f3a\u9677\u548c\u63d0\u65e9\u8870\u8001\u7279\u5fb5\u5728\u7ae5\u5e74\u671f\u9593\u9010\u6f38\u767c\u5c55\u3002  <\/strong><\/li>\n\n\n\n<li><strong>\u8457\u8272\u6027\u4e7e\u76ae\u75c7\uff08XP\uff09\u3002\u7531\u6838\u82f7\u9178\u5207\u9664\u4fee\u5fa9\u4e2d\u7684 XPA \u53ca\u76f8\u95dc\u7a81\u8b8a\u5f15\u8d77\u3002\u76ae\u819a\u764c\u98a8\u96aa\u6975\u9ad8\uff0c\u90e8\u5206\u75c5\u4eba\u51fa\u73fe\u56b4\u91cd\u795e\u7d93\u9000\u5316\u3002  <\/strong><\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u56db\u8005\u90fd\u6709\u4e00\u500b\u5171\u540c\u7684\u6839\u672c\u554f\u984c\uff1aDNA \u4fee\u5fa9\u7cfb\u7d71\u7121\u6cd5\u6b63\u5e38\u904b\u4f5c\u3002\u5065\u5eb7\u7d30\u80de\u672c\u6703\u4fee\u5fa9\u7684\u640d\u50b7\u53cd\u800c\u7d2f\u7a4d\u8d77\u4f86\uff0c\u7522\u751f\u6f38\u9032\u7684\u7d30\u80de\u529f\u80fd\u969c\u7919\u548c\u7d30\u80de\u6b7b\u4ea1\uff0c\u800c\u9019\u4e9b\u7d30\u80de\u7684\u6d41\u5931\u8868\u73fe\u70ba\u5668\u5b98\u529f\u80fd\u8870\u7aed\u3002\u767c\u75c5\u6642\u9593\u5f9e\u5b30\u5152\u671f\u5230\u9752\u6625\u671f\u5f8c\u4e0d\u7b49\u3002\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u767d\u5167\u969c\u3001\u795e\u7d93\u9000\u5316\u3001\u611f\u67d3\u548c\u764c\u75c7\u7684\u98a8\u96aa\u9060\u9ad8\u65bc\u4e00\u822c\u4eba\u7fa4\u3002\u5c0d\u9019\u4e9b\u75c5\u4eba\u800c\u8a00\uff0c\u5373\u4f7f\u662f\u967d\u5149\u4e5f\u6709\u4ee3\u50f9\uff1a\u7d2b\u5916\u7dda\u6703\u640d\u5bb3\u76ae\u819a\u7d30\u80de\u7684 DNA\uff0c\u800c\u4ed6\u5011\u7684\u4fee\u5fa9\u6a5f\u5236\u7121\u6cd5\u4fee\u5fa9\u3002    <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7d50\u679c\u662f\u65e2\u88ab\u58d3\u7e2e\u53c8\u88ab\u52a0\u901f\u7684\u751f\u547d\u3002\u5c0d\u63d0\u65e9\u8870\u8001\u75be\u75c5\u60a3\u8005\u4f86\u8aaa\uff0c\u8870\u8001\u7684\u8ca0\u64d4\u6bd4\u61c9\u6709\u7684\u6642\u9593\u63d0\u65e9\u6578\u5341\u5e74\u5230\u4f86\u3002 <\/strong><\/p>\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"667\" height=\"667\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/09\/image-5.jpg\" alt=\"\" class=\"wp-image-29733\" style=\"aspect-ratio:1;width:534px;height:auto\" title=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/09\/image-5.jpg 667w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/09\/image-5-150x150.png 150w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/09\/image-5-300x300.png 300w\" sizes=\"(max-width: 667px) 100vw, 667px\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c 04 \u90e8\u5206\uff1a\u63d0\u65e9\u8870\u8001\u5982\u4f55\u8017\u76e1\u7d30\u80de NAD+<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u628a\u9019\u4e9b\u75be\u75c5\u8207 NAD+ \u806f\u7e6b\u8d77\u4f86\u7684\u6a5f\u5236\u662f\u7279\u5b9a\u7684\uff0c\u800c\u975e\u7c60\u7d71\u7684\u3002\u6301\u7e8c\u7684 DNA \u640d\u50b7\u4ee4 PARP1 \u4fdd\u6301\u6d3b\u8e8d\uff0c\u800c PARP1 \u662f\u7d30\u80de\u5167 NAD+ \u7684\u4e3b\u8981\u6d88\u8017\u8005\u4e4b\u4e00\u3002\u6301\u7e8c\u6fc0\u6d3b\u6703\u8017\u76e1\u5132\u5099\uff0c\u7559\u7d66 SIRT1 \u7684\u53d7\u8cea\u66f4\u5c11 \u2014\u2014SIRT1 \u662f\u4f9d\u8cf4 NAD+ \u53ef\u7528\u6027\u4f86\u57f7\u884c\u5176\u5728\u80fd\u91cf\u8abf\u7bc0\u548c\u7c92\u7dda\u9ad4\u8cea\u91cf\u63a7\u5236\u4e2d\u89d2\u8272\u7684\u9176\u3002SIRT1 \u6d3b\u6027\u964d\u4f4e\u5f8c\uff0c\u80fd\u91cf\u7522\u751f\u548c\u7c92\u7dda\u9ad4\u81ea\u566c\u53d7\u5230\u5f71\u97ff\uff0c\u7d30\u80de\u8d70\u5411\u56b4\u91cd\u529f\u80fd\u969c\u7919\u6216\u6b7b\u4ea1\uff08Bohr, 2026\uff09\u3002   <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u70ba\u751a\u9ebc\u63d0\u65e9\u8870\u8001\u7d30\u80de\u6703\u8017\u76e1 NAD+<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u9019\u500b\u5e8f\u5217\u6b63\u662f NAD+ \u88dc\u5145\u5728\u6b64\u60c5\u5883\u4e0b\u6210\u70ba\u5408\u7406\u5047\u8a2d\u3001\u800c\u975e\u7c60\u7d71\u9577\u58fd\u5ba3\u7a31\u7684\u539f\u56e0\u3002\u5982\u679c NAD+ \u8017\u7aed\u662f\u75c5\u7406\u4e2d\u7684\u4e00\u6b65\uff0c\u90a3\u9ebc\u4f9b\u61c9\u524d\u9ad4\u5c31\u53ef\u80fd\u5408\u7406\u5730\u4fdd\u8b77\u90a3\u4e9b\u57fa\u56e0\u5c64\u9762\u7f3a\u9677\u7121\u6cd5\u4fee\u6b63\u7684\u75c5\u4eba\u7684\u7d30\u80de\u529f\u80fd\u548c\u5b58\u6d3b\u3002\u9019\u500b\u5047\u8a2d\u9996\u5148\u5728\u6a21\u5f0f\u751f\u7269\u4e2d\u5f97\u5230\u6e2c\u8a66\uff0c\u5728\u6e90\u81ea\u9019\u4e9b\u75c5\u4eba\u7684\u7d30\u80de\u4e2d\uff0c\u63d0\u5347 NAD+ \u6539\u5584\u4e86\u7c92\u7dda\u9ad4\u529f\u80fd\u4e26\u6e1b\u5c11\u4e86\u8870\u8001\u6a19\u8a18\uff08Bohr, 2026\uff09\u3002  <\/strong><\/p>\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"693\" height=\"438\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/09\/image.gif\" alt=\"\" class=\"wp-image-29734\" style=\"aspect-ratio:1.582857142857143;width:554px;height:auto\" title=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/09\/image.gif 693w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/09\/image-300x190.png 300w\" sizes=\"(max-width: 693px) 100vw, 693px\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\"><strong>(\u4e00\u540d\u6c83\u7d0d\u7d9c\u5408\u75c7\u75c5\u4eba 15 \u6b72\uff08\u5de6\uff09\u8207 48 \u6b72\uff08\u53f3\uff09\u7684\u5c0d\u6bd4\u3002\u5716\u7247\u4f86\u6e90:<\/strong> <strong><a href=\"https:\/\/www.eurekalert.org\/multimedia\/1076498\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.eurekalert.org\/multimedia\/1076498<\/a><\/strong><strong>)<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c 05 \u90e8\u5206\uff1a\u7159\u9170\u80fa\u6838\u82f7\u5728\u63d0\u65e9\u8870\u8001\u75be\u75c5\u4e2d\u7684\u81e8\u5e8a\u8a66\u9a57<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7159\u9170\u80fa\u6838\u82f7\uff08NR\uff09\u662f\u4e00\u7a2e\u53e3\u670d NAD+ \u524d\u9ad4\uff0c\u80fd\u53ef\u9760\u5730\u63d0\u9ad8\u4eba\u9ad4\u8840\u6db2 NAD+\u3002\u76ee\u524d\u5df2\u6709\u4e09\u9805\u8a66\u9a57\u5728\u5169\u7a2e\u9019\u985e\u63d0\u65e9\u8870\u8001\u75be\u75c5\u4e2d\u5c0d\u5b83\u9032\u884c\u6e2c\u8a66\u3002 <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7159\u9170\u80fa\u6838\u82f7\u8207\u6c83\u7d0d\u7d9c\u5408\u75c7<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u6c83\u7d0d\u7d9c\u5408\u75c7\u7684\u7b2c\u4e00\u9805\u5c0d\u7167\u6e2c\u8a66\u662f\u4e00\u9805\u70ba\u671f 52 \u9031\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u4ea4\u53c9\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u5171 9 \u540d\u5e73\u5747\u5e74\u9f61 47 \u6b72\u7684\u75c5\u4eba\uff08Shoji et al., 2025\uff09\u3002\u53c3\u8207\u8005\u6bcf\u5929\u670d\u7528 1,000 mg NR \u6216\u5b89\u6170\u5291 26 \u9031\uff0c\u7136\u5f8c\u4ea4\u53c9\u5230\u53e6\u4e00\u7d44 26 \u9031\u3002\u670d\u7528 NR \u5f8c\uff0c\u8840\u6f3f NAD+ \u4e0a\u5347\u7d04 140%\u3002\u8a66\u9a57\u4ea6\u5831\u544a\u4e86\u52d5\u8108\u50f5\u786c\u5ea6\u4e0b\u964d\u3001\u8207\u5fc3\u8840\u7ba1\u4fdd\u8b77\u76f8\u95dc\u7684\u8102\u8cea\u8b8a\u5316\u3001\u652f\u6301\u50b7\u53e3\u7652\u5408\u548c\u814e\u529f\u80fd\u6539\u5584\u3002Shoji \u5718\u968a\u4ea6\u5831\u544a NR \u7d44\u6709 7 \u4f8b\u8f15\u5ea6\u4e0d\u826f\u4e8b\u4ef6\u3001\u5b89\u6170\u5291\u7d44\u6709 12 \u4f8b\uff0c\u540c\u6642\u89c0\u5bdf\u5230\u809d\u9176\u7684\u8f15\u5ea6\u5347\u9ad8\u3002\u4f5c\u8005\u7e3d\u7d50\u6307\u9019\u4e9b\u4e8b\u4ef6\u53ef\u63a7\uff0c\u4e26\u8207\u6c83\u7d0d\u7d9c\u5408\u75c7\u672c\u8eab\u5e38\u898b\u7684\u809d\u81df\u654f\u611f\u4e00\u81f4\u3002\u4f5c\u8005\u628a\u7d50\u679c\u63cf\u8ff0\u70ba\u652f\u6301\u9032\u4e00\u6b65\u7814\u7a76\uff0c\u800c\u975e\u5df2\u78ba\u7acb\u7684\u76ca\u8655\uff0c\u800c\u4e14 9 \u540d\u53c3\u8207\u8005\u662f\u4e00\u500b\u96e3\u4ee5\u63a8\u8ad6\u7684\u5c0f\u7fa4\u7d44\u3002      <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7159\u9170\u80fa\u6838\u82f7\u8207\u5171\u6fdf\u5931\u8abf &#8211; \u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u75c7<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u4e00\u9805\u8f03\u65e9\u671f\u7684\u958b\u653e\u6a19\u7c64\u7814\u7a76\uff0c\u4ee5\u6bcf\u5929\u6bcf\u516c\u65a4\u9ad4\u91cd 25 mg \u7684\u5291\u91cf\u6cbb\u7642 24 \u540d\u5171\u6fdf\u5931\u8abf &#8211; \u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u75c7\u75c5\u4eba\u56db\u500b\u6708\uff0c\u7136\u5f8c\u5728\u7121\u6cbb\u7642\u7684\u60c5\u6cc1\u4e0b\u8ddf\u9032\u5169\u500b\u6708\uff08Veenhuis et al., 2021\uff09\u3002\u6cbb\u7642\u671f\u9593\u5171\u6fdf\u5931\u8abf\u8a55\u5206\u6709\u6240\u6539\u5584\uff1a\u5728\u5171\u6fdf\u5931\u8abf\u8a55\u4f30\u8207\u8a55\u5206\u91cf\u8868\uff08Scale for the Assessment and Rating of Ataxia\uff09\u4e0a\u5e73\u5747\u7e3d\u5206\u964d\u81f3 2.4\uff0c\u5728\u570b\u969b\u5408\u4f5c\u5171\u6fdf\u5931\u8abf\u8a55\u5206\u91cf\u8868\uff08International Cooperative Ataxia Rating Scale\uff09\u4e0a\u964d\u81f3 10.1\u3002\u514d\u75ab\u7f3a\u9677\u75c5\u4eba\u7684\u8840\u6e05 IgG \u51fa\u73fe\u6301\u7e8c\u4e0a\u5347\u3002\u6c92\u6709\u5831\u544a\u4e0d\u826f\u4e8b\u4ef6\u3002\u6cbb\u7642\u505c\u6b62\u5f8c\uff0c\u6539\u5584\u51fa\u73fe\u9006\u8f49\uff0c\u800c\u8a72\u7814\u7a76\u6c92\u6709\u5b89\u6170\u5291\u7d44\u3002    <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u4e00\u9805\u66f4\u9577\u671f\u7684\u55ae\u81c2\u7814\u7a76\u4ee5\u6bcf\u5929 500 mg NR \u6cbb\u7642 10 \u540d\u5171\u6fdf\u5931\u8abf &#8211; \u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u75c7\u75c5\u4eba\u5169\u5e74\uff08Presterud et al., 2024\uff09\u3002\u8840\u6db2 NAD+ \u8fc5\u901f\u4e0a\u5347\u4e26\u7dad\u6301\u5728\u57fa\u7dda\u4e4b\u4e0a\u3002\u5728 18 \u500b\u6708\u8a55\u4f30\u6642\uff0c\u9664\u4e00\u540d\u53c3\u8207\u8005\u5916\uff0c\u6240\u6709\u4eba\u90fd\u5728\u4e00\u7d44\u795e\u7d93\u904b\u52d5\u6e2c\u8a66\u4e2d\u6709\u6240\u6539\u5584\uff0c\u4e3b\u8981\u7531\u5354\u8abf\u548c\u773c\u7403\u904b\u52d5\u5b50\u9805\u5206\u6578\u5e36\u52d5\uff0c\u800c\u8207\u6b77\u53f2\u6578\u64da\u6bd4\u8f03\u5247\u986f\u793a\u9032\u5c55\u6bd4\u9810\u671f\u7de9\u6162\u3002\u9019\u4ecd\u7136\u662f\u6b77\u6642\u6700\u9577\u7684 NR \u8a66\u9a57\uff0c\u986f\u793a\u5927\u591a\u6578\u53c3\u8207\u8005\u5c0d NR \u8010\u53d7\u826f\u597d\uff1b\u7136\u800c\uff0c\u7f3a\u4e4f\u5c0d\u7167\u7d44\u9650\u5236\u4e86\u5b83\u80fd\u5f97\u51fa\u7684\u7d50\u8ad6\u3002   <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7d9c\u5408\u4f86\u770b\uff0c\u4e09\u9805\u8a66\u9a57\u6307\u5411\u540c\u4e00\u65b9\u5411\uff0c\u4f46\u672a\u6709\u5b9a\u8ad6\u3002\u6a23\u672c\u4eba\u6578\u5c11\uff0c\u4e09\u9805\u4e2d\u6709\u5169\u9805\u662f\u958b\u653e\u6a19\u7c64\uff0c\u800c\u4e14\u6240\u6709\u8a66\u9a57\u62db\u52df\u7684\u90fd\u662f\u5df2\u78ba\u8a3a\u907a\u50b3\u75be\u75c5\u7684\u75c5\u4eba\uff0c\u800c\u975e\u5065\u5eb7\u6210\u5e74\u4eba\u3002\u5b83\u5011\u652f\u6301\u5728\u63d0\u65e9\u8870\u8001\u75be\u75c5\u4e2d\u7e7c\u7e8c\u7814\u7a76\uff0c\u4f46\u4e0d\u652f\u6301\u6709\u95dc\u4e00\u822c\u4eba\u7fa4\u6297\u8870\u8001\u6548\u679c\u7684\u5ba3\u7a31\u3002   <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c 06 \u90e8\u5206\uff1a\u7d50\u8ad6\uff1a\u63d0\u65e9\u8870\u8001\u4e26\u975e NAD+ \u8a34\u8aaa\u7684\u552f\u4e00\u6545\u4e8b<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u8b49\u64da\u73fe\u5728\u5206\u70ba\u4e09\u5c64\u3002\u751f\u7269\u5b78\u662f\u6e05\u6670\u7684 \u2014\u2014NAD+ \u8017\u7aed\u662f DNA \u4fee\u5fa9\u7f3a\u9677\u7684\u5df2\u8a18\u9304\u5f8c\u679c\uff1aPARP1 \u7684\u6301\u7e8c\u6d3b\u6027\u8017\u76e1\u4e86 SIRT1 \u6240\u4f9d\u8cf4\u7684\u540c\u4e00\u500b\u5132\u5099\uff08Bohr, 2026\uff09\u3002\u4eba\u7fa4\u6578\u64da\u5247\u66f4\u70ba\u96dc\u4e82\uff0c\u986f\u793a\u7684\u4e0b\u964d\u65e2\u4e0d\u5747\u52fb\u4e5f\u4e0d\u9661\u5ced\uff0c\u4e14\u56e0\u6027\u5225\u800c\u7570\uff08Yang et al., 2022\uff09\u3002\u4eba\u9ad4\u8a66\u9a57\u4ecd\u5c6c\u65e9\u671f\u3001\u898f\u6a21\u5c0f\u3001\u4e14\u50c5\u9650\u65bc\u7f55\u898b\u75be\u75c5\uff08Shoji et al., 2025; Veenhuis et al., 2021; Presterud et al., 2024\uff09\u3002   <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u4e5f\u503c\u5f97\u5766\u7387\u8aaa\u660e\u88dc\u5145\u54c1\u505a\u4e0d\u5230\u7684\u4e8b\u60c5\u3002\u5b83\u4e0d\u80fd\u4fee\u6b63\u7a81\u8b8a\u7684 WRN\u3001ATM \u6216 XPA \u57fa\u56e0\uff0c\u4e5f\u4e0d\u80fd\u53d6\u4ee3\u57fa\u56e0\u6cbb\u7642\u3001\u652f\u63f4\u6027\u8b77\u7406\u6216\u907a\u50b3\u8aee\u8a62\u3002\u5c0d\u9762\u5c0d\u5176\u4e2d\u4e00\u500b\u8a3a\u65b7\u7684\u5bb6\u5ead\u800c\u8a00\uff0c\u88dc\u5145\u54c1\u4e0d\u662f\u6539\u8b8a\u6839\u672c\u75be\u75c5\u7684\u5e72\u9810\u624b\u6bb5\uff0c\u800c\u5c0d\u63d0\u65e9\u8870\u8001\u75be\u75c5\u4f86\u8aaa\uff0c\u5c0b\u627e\u9019\u7a2e\u5e72\u9810\u7684\u5de5\u4f5c\u4ecd\u5728\u7e7c\u7e8c\u3002  <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u9019\u88e1\u9700\u8981\u4e00\u500b\u9069\u7528\u7bc4\u570d\u8aaa\u660e\u3002\u4e0a\u8ff0\u8a66\u9a57\u6e2c\u8a66\u7684\u662f\u7159\u9170\u80fa\u6838\u82f7\uff0c\u800c\u975e\u4efb\u4f55\u7279\u5b9a\u54c1\u724c\u92b7\u552e\u7684 NADH \u5291\u578b\u3002Celfull \u95dc\u6ce8\u9019\u9805\u7814\u7a76\uff0c\u662f\u56e0\u70ba NAD+ \u4ee3\u8b1d\u662f\u516c\u53f8\u6240\u5c6c\u7684\u9818\u57df\uff0c\u800c\u4ee5\u4e0a\u6240\u8ff0\u6c92\u6709\u4efb\u4f55\u4e00\u9805\u61c9\u88ab\u89e3\u8b80\u70ba\u7522\u54c1\u5ba3\u7a31\u3002  <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u9019\u4e9b\u90fd\u4e0d\u80fd\u53d6\u4ee3\u81e8\u5e8a\u91ab\u751f\u3002\u5728\u7f55\u898b\u907a\u50b3\u75be\u75c5\u4e2d\uff0c\u6709\u95dc\u88dc\u5145\u54c1\u7684\u6c7a\u5b9a\u5c6c\u65bc\u6cbb\u7642\u5718\u968a\uff1b\u800c\u5728\u5065\u5eb7\u6210\u5e74\u4eba\u4e2d\uff0c\u5e38\u898f\u4f7f\u7528\u7684\u7406\u64da\u5c1a\u672a\u78ba\u7acb\u3002 <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u65e9\u671f\u8a66\u9a57\u771f\u6b63\u6539\u8b8a\u7684\u662f\u6846\u67b6\u3002\u5728\u4e00\u7a2e\u901a\u5e38\u9032\u5c55\u8fc5\u901f\u7684\u75be\u75c5\u4e2d\u53d6\u5f97\u7de9\u6162\u9032\u5c55\uff0c\u4e0d\u662f\u6cbb\u7652\uff0c\u4e5f\u5f9e\u4f86\u4e0d\u53ef\u80fd\u662f\u3002\u5b83\u662f\u7b2c\u4e00\u500b\u8a0a\u865f\uff0c\u8868\u660e\u554f\u984c\u7784\u6e96\u4e86\u6b63\u78ba\u7684\u5730\u65b9\u3002  <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>References<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>Bohr V A. Promising Results With NAD Supplementation in Rare Diseases With Premature Aging and DNA Damage[J]. Aging Cell, 2026, 25(1): e70319.<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41436848\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/41436848\/<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>Shoji M, Kato H, Koshizaka M, et al. Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial[J]. Aging Cell, 2025, 24(8): e70093.<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41436848\/\" rel=\"nofollow noopener\" target=\"_blank\"> <\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40459998\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/40459998\/<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>Veenhuis S J G, van Os N J H, Janssen A J W M, et al. Nicotinamide riboside improves ataxia scores and immunoglobulin levels in ataxia telangiectasia[J]. Movement Disorders, 2021, 36(12): 2951-2957.<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34515380\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34515380\/<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>Presterud R, Deng W H, Wennerstr\u00f6m A B, et al. Long-term nicotinamide riboside use improves coordination and eye movements in ataxia telangiectasia[J]. Movement Disorders, 2024, 39(2): 360-369.<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37899683\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37899683\/<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>Yang F, Deng X, Yu Y, et al. Association of Human Whole Blood NAD+ Contents With Aging[J]. Frontiers in Endocrinology, 2022, 13: 829658.<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35388296\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35388296\/<\/a><\/p>\n\n<p class=\"wp-block-paragraph\">\u514d\u8cac\u8072\u660e\uff1a\u6b64\u7b49\u9673\u8ff0\u672a\u7d93\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u8a55\u4f30\u3002\u672c\u6587\u6240\u8ff0\u8cc7\u8a0a\u53ca\u6210\u5206\u50c5\u4f9b\u7814\u7a76\u7528\u9014\uff0c\u4e26\u975e\u7528\u65bc\u8a3a\u65b7\u3001\u6cbb\u7642\u3001\u6cbb\u7652\u6216\u9810\u9632\u4efb\u4f55\u75be\u75c5\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u63d0\u65e9\u8870\u8001\u75be\u75c5\u662f NAD+ \u7814\u7a76\u8fc4\u4eca\u7522\u751f\u6700\u5177\u9ad4\u4eba\u985e\u6210\u679c\u7684\u9818\u57df\u3002NAD+ \u662f\u7d30\u80de\u80fd\u91cf\u4ee3\u8b1d\u6838\u5fc3\u7684\u8f14\u9176\uff0c\u6578\u767e\u7bc7\u8ad6\u6587\u63cf\u8ff0 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":29744,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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