{"id":29770,"date":"2026-01-30T13:47:00","date_gmt":"2026-01-30T18:47:00","guid":{"rendered":"https:\/\/www.celfull.com\/%e6%9c%aa%e5%88%86%e9%a1%9e\/nature-metabolism-mitochondrial-nad-homeostasis-regulates-liver-regeneration.html"},"modified":"2026-09-21T03:25:23","modified_gmt":"2026-09-21T07:25:23","slug":"nature-metabolism-mitochondrial-nad-homeostasis-regulates-liver-regeneration","status":"publish","type":"post","link":"https:\/\/www.celfull.com\/zh-hant\/%e6%96%b0%e8%81%9e\/nature-metabolism-mitochondrial-nad-homeostasis-regulates-liver-regeneration.html","title":{"rendered":"\u7c92\u7dda\u9ad4 NAD+ \u7a69\u614b\u8abf\u63a7\u809d\u81df\u518d\u751f"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">NAD+ \u662f\u4e3b\u5c0e\u7d30\u80de\u6c27\u5316\u9084\u539f\u53cd\u61c9\u3001\u80fd\u91cf\u4ee3\u8b1d\u548c\u4fe1\u865f\u8f49\u5c0e\u7684\u4e0d\u53ef\u6216\u7f3a\u7684\u6838\u5fc3\u8f14\u9176\u3002\u5176\u4ee3\u8b1d\u5931\u8861\u8207\u591a\u7a2e\u6162\u6027\u75be\u75c5\u548c\u5668\u5b98\u529f\u80fd\u969c\u7919\u5bc6\u5207\u76f8\u95dc\u3002\u96d6\u7136\u5927\u91cf\u7814\u7a76\u5df2\u8b49\u5be6\u88dc\u5145 NAD+ \u524d\u9ad4\u80fd\u6539\u5584\u7d44\u7e54\u4fee\u5fa9\u548c\u4ee3\u8b1d\u5065\u5eb7\uff0c\u4f46\u4e9e\u7d30\u80de\u5c64\u9762\u4e0a\u7c92\u7dda\u9ad4 NAD+ \u5c0d\u809d\u81df\u518d\u751f\u7684\u8abf\u63a7\u6a5f\u5236\uff0c\u9577\u671f\u4ee5\u4f86\u4e00\u76f4\u672a\u660e\u3002\u8cd3\u5915\u6cd5\u5c3c\u4e9e\u5927\u5b78\u7814\u7a76\u5718\u968a\u767c\u8868\u65bc Nature Metabolism \u7684\u4e00\u9805 2025 \u5e74 12 \u6708\u6a19\u8a8c\u6027\u7814\u7a76\uff0c\u7d42\u65bc\u95e1\u660e\u4e86\u9019\u4e00\u6838\u5fc3\u5967\u79d8\uff1a\u809d\u7d30\u80de\u7c92\u7dda\u9ad4 NAD+ \u5132\u5eab\u5bb9\u91cf\u662f\u809d\u81df\u518d\u751f\u7684\u95dc\u9375\u9650\u5236\u56e0\u7d20\uff0c\u800c SLC25A51 \u8f49\u904b\u86cb\u767d\u5247\u5145\u7576\u63a7\u5236\u809d\u81df\u4fee\u5fa9\u6548\u7387\u7684\u6838\u5fc3\u958b\u95dc\u3002   <\/p>\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"692\" height=\"229\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-10.png\" alt=\"\" class=\"wp-image-27247\" title=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-10.png 692w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-10-300x99.png 300w\" sizes=\"(max-width: 692px) 100vw, 692px\" \/><\/figure>\n\n<h3 class=\"wp-block-heading\">1. NAD+ \u7684\u4e9e\u7d30\u80de\u5340\u9694\uff1a\u70ba\u751a\u9ebc\u6574\u9ad4\u88dc\u5145\u7121\u6cd5\u4fdd\u8b49\u809d\u81df\u4fee\u5fa9<\/h3>\n\n<p class=\"wp-block-paragraph\">\u7d30\u80de\u5167 NAD+ \u5448\u56b4\u683c\u7684\u5340\u9694\u5316\u5206\u4f48\uff0c\u5728\u7c92\u7dda\u9ad4\u3001\u7d30\u80de\u8cea\u548c\u7d30\u80de\u6838\u4e2d\u5206\u5225\u5f62\u6210\u76f8\u5c0d\u7368\u7acb\u7684\u4ee3\u8b1d\u5132\u5eab\u3002\u6bcf\u500b\u4e9e\u7d30\u80de NAD+ \u5132\u5eab\u627f\u64d4\u5b8c\u5168\u4e0d\u540c\u7684\u751f\u7406\u529f\u80fd\uff0c\u5f7c\u6b64\u4e0d\u53ef\u4e92\u76f8\u66ff\u4ee3\u3002\u9019\u6b63\u662f\u5e38\u898f\u5168\u8eab\u6027 NAD+ \u88dc\u5145\u5728\u809d\u81df\u4fee\u5fa9\u6548\u679c\u4e0a\u53c3\u5dee\u4e0d\u9f4a\u7684\u6839\u672c\u539f\u56e0\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u4ee5\u5f80\u7814\u7a76\u8b49\u5be6\uff0c\u5168\u8eab\u6027 NAD+ \u524d\u9ad4\u651d\u5165\u6709\u52a9\u65bc\u6539\u5584\u809d\u81df\u518d\u751f\uff0c\u4f46\u672a\u80fd\u78ba\u5b9a\u54ea\u500b\u4e9e\u7d30\u80de\u5132\u5eab\u8d77\u6c7a\u5b9a\u6027\u4f5c\u7528\u3002\u9019\u9805 2025 \u5e74\u7814\u7a76\u63a1\u7528\u524d\u6cbf\u7684 NAD-SILEC \u7a69\u5b9a\u540c\u4f4d\u7d20\u6a19\u8a18\u7d50\u5408\u4e9e\u7d30\u80de\u5206\u993e\u6280\u8853\uff0c\u7cbe\u6e96\u8ffd\u8e64\u4e86\u809d\u81df\u4fee\u5fa9\u904e\u7a0b\u4e2d NAD+ \u7684\u52d5\u614b\u8b8a\u5316\u3002\u5be6\u9a57\u7d50\u679c\u6e05\u695a\u986f\u793a\uff0c\u53ea\u6709\u7c92\u7dda\u9ad4 NAD+ \u6c34\u5e73\u8207\u809d\u81df\u518d\u751f\u901f\u5ea6\u5448\u9ad8\u5ea6\u540c\u6b65\u6ce2\u52d5\uff1b\u7d30\u80de\u8cea NAD+ \u5728\u6574\u500b\u4fee\u5fa9\u904e\u7a0b\u4e2d\u4fdd\u6301\u7a69\u5b9a\uff0c\u8207\u7d44\u7e54\u6062\u5fa9\u6548\u7387\u6c92\u6709\u986f\u8457\u76f8\u95dc\u6027\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u9019\u4e00\u7a81\u7834\u6027\u767c\u73fe\u78ba\u7acb\u4e86\u7c92\u7dda\u9ad4 NAD+ \u5c0d\u809d\u81df\u518d\u751f\u7684\u529f\u80fd\u7279\u7570\u6027\uff1a\u809d\u81df\u7d44\u7e54\u4fee\u5fa9\u5b8c\u5168\u4f9d\u8cf4\u5145\u8db3\u7684\u7c92\u7dda\u9ad4 NAD+ \u4f9b\u61c9\uff0c\u4ee5\u652f\u6301\u9ad8\u5f37\u5ea6\u80fd\u91cf\u4ee3\u8b1d\u548c\u7d30\u80de\u751f\u7269\u5408\u6210\uff0c\u800c\u7d30\u80de\u8cea NAD+ \u7121\u6cd5\u88dc\u511f\u7c92\u7dda\u9ad4\u4e0d\u8db3\u3002\u5b83\u5f9e\u6839\u672c\u4e0a\u89e3\u91cb\u4e86\u76f2\u76ee\u88dc\u5145 NAD+ \u7684\u5c40\u9650\uff0c\u4e26\u70ba\u7cbe\u6e96\u809d\u81df\u4ee3\u8b1d\u8abf\u63a7\u5960\u5b9a\u4e86\u7406\u8ad6\u57fa\u790e\u3002 <\/p>\n\n<h3 class=\"wp-block-heading\">2. SLC25A51\uff1a\u809d\u7d30\u80de\u4e2d\u552f\u4e00\u7684\u7c92\u7dda\u9ad4 NAD+ \u8f49\u904b\u86cb\u767d<\/h3>\n\n<p class=\"wp-block-paragraph\">\u7c92\u7dda\u9ad4\u5167\u819c\u5177\u6709\u9078\u64c7\u6027\u901a\u900f\u6027\uff0c\u610f\u5473\u7740\u7d30\u80de\u5916\u548c\u7d30\u80de\u8cea\u4e2d\u7684 NAD+ \u4e0d\u80fd\u81ea\u7531\u9032\u5165\u7c92\u7dda\u9ad4\u57fa\u8cea\uff0c\u5fc5\u9808\u4f9d\u8cf4\u7279\u5b9a\u7684\u8f49\u904b\u86cb\u767d\u5b8c\u6210\u8de8\u819c\u904b\u8f38\u3002\u5728\u6b64\u7814\u7a76\u4e4b\u524d\uff0c\u5b78\u8853\u754c\u666e\u904d\u63a8\u6e2c SLC25A47 \u662f\u809d\u7d30\u80de\u95dc\u9375\u7684\u7c92\u7dda\u9ad4 NAD+ \u8f49\u904b\u86cb\u767d\u3002\u7136\u800c\uff0c\u672c\u7814\u7a76\u4e2d\u7684\u591a\u9805\u56b4\u683c\u529f\u80fd\u9a57\u8b49\u5be6\u9a57\u5fb9\u5e95\u63a8\u7ffb\u4e86\u9019\u4e00\u7d50\u8ad6\uff0c\u4e26\u78ba\u8a8d SLC25A51 \u662f\u552f\u4e00\u7684\u6838\u5fc3\u4ecb\u5c0e\u8005\u3002  <\/p>\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"692\" height=\"154\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-11.png\" alt=\"\" class=\"wp-image-27248\" title=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-11.png 692w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-11-300x67.png 300w\" sizes=\"(max-width: 692px) 100vw, 692px\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\">\u57fa\u56e0\u6c89\u9ed8\u8207\u904e\u8868\u9054\u7d30\u80de\u5be6\u9a57\uff1a\u5728 HeLa \u7d30\u80de\u548c HepG2 \u4eba\u809d\u7d30\u80de\u4e2d\uff0c\u6c89\u9ed8 SLC25A51 \u8868\u9054\u986f\u8457\u964d\u4f4e\u4e86\u7c92\u7dda\u9ad4 NAD+ \u542b\u91cf\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u904e\u8868\u9054 SLC25A47 \u5c0d\u7c92\u7dda\u9ad4 NAD+ \u6c34\u5e73\u6c92\u6709\u7522\u751f\u660e\u986f\u6539\u8b8a\uff0c\u521d\u6b65\u5426\u5b9a\u4e86 SLC25A47 \u7684\u8abf\u63a7\u529f\u80fd\u3002 <\/p>\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"562\" height=\"299\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-13.png\" alt=\"\" class=\"wp-image-27250\" title=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-13.png 562w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-13-300x160.png 300w\" sizes=\"(max-width: 562px) 100vw, 562px\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\">\u809d\u7d30\u80de\u7279\u7570\u6027\u57fa\u56e0\u6572\u9664\u52d5\u7269\u9a57\u8b49\uff1a\u5728 SLC25A47 \u6572\u9664\u5c0f\u9f20\u4e2d\uff0c\u809d\u81df\u7c92\u7dda\u9ad4 NAD+ \u542b\u91cf\u4fdd\u6301\u6b63\u5e38\u7a69\u5b9a\uff0c\u9032\u4e00\u6b65\u8b49\u660e SLC25A47 \u5728\u809d\u81df\u7d44\u7e54\u4e2d\u4e0d\u5177\u6709 NAD+ \u8f49\u904b\u80fd\u529b\u3002<\/p>\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"692\" height=\"265\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-12.png\" alt=\"\" class=\"wp-image-27249\" title=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-12.png 692w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-12-300x115.png 300w\" sizes=\"(max-width: 692px) 100vw, 692px\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\">\u7c92\u7dda\u9ad4\u9776\u5411\u8f49\u904b\u6d3b\u6027\u6e2c\u5b9a\uff1a\u5229\u7528 mitoPARP1cd \u6aa2\u6e2c\u7cfb\u7d71\uff0c\u7814\u7a76\u4eba\u54e1\u76f4\u89c0\u9a57\u8b49\u4e86 SLC25A51 \u80fd\u9ad8\u6548\u4ecb\u5c0e NAD+ \u9032\u5165\u7c92\u7dda\u9ad4\u57fa\u8cea\uff0c\u800c SLC25A47 \u5b8c\u5168\u4e0d\u5177\u5099\u9019\u7a2e\u8f49\u904b\u6d3b\u6027\u3002\u9019\u78ba\u8a8d\u4e86 SLC25A51 \u7684\u8868\u9054\u6c34\u5e73\u76f4\u63a5\u6c7a\u5b9a\u7c92\u7dda\u9ad4 NAD+ \u5132\u5eab\u5927\u5c0f\uff0c\u662f\u7c92\u7dda\u9ad4 NAD+ \u809d\u81df\u518d\u751f\u7684\u6838\u5fc3\u8abf\u63a7\u6a1e\u7d10\u3002 <\/p>\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"692\" height=\"453\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-14.png\" alt=\"\" class=\"wp-image-27251\" title=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-14.png 692w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-14-300x196.png 300w\" sizes=\"(max-width: 692px) 100vw, 692px\" \/><\/figure>\n\n<h3 class=\"wp-block-heading\">3. \u6838\u5fc3\u6a5f\u5236\uff1a\u7c92\u7dda\u9ad4 NAD+ \u5982\u4f55\u63a7\u5236\u809d\u81df\u518d\u751f\u6548\u7387<\/h3>\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u5718\u968a\u69cb\u5efa\u4e86\u5169\u500b\u7cbe\u6e96\u52d5\u7269\u6a21\u578b \u2014\u2014SLC25A51 \u96dc\u5408\u7f3a\u5931\uff08Slc25a51+\/-\uff09\u548c\u809d\u7d30\u80de\u7279\u7570\u6027 SLC25A51 \u904e\u8868\u9054 \u2014\u2014 \u7cfb\u7d71\u95e1\u8ff0\u4e86\u7c92\u7dda\u9ad4 NAD+ \u809d\u81df\u518d\u751f\u6db5\u84cb\u80fd\u91cf\u4ee3\u8b1d\u8207\u8102\u8cea\u7a69\u614b\u7684\u96d9\u91cd\u8abf\u63a7\u6a5f\u5236\u3002<\/p>\n\n<h4 class=\"wp-block-heading\">3.1 \u7c92\u7dda\u9ad4 NAD+ \u4e0d\u8db3\u5b8c\u5168\u963b\u65b7\u809d\u81df\u4fee\u5fa9<\/h4>\n\n<p class=\"wp-block-paragraph\">Slc25a51+\/- \u5c0f\u9f20\u809d\u81df\u7c92\u7dda\u9ad4 NAD+ \u542b\u91cf\u986f\u8457\u4e0b\u964d\uff0c\u90e8\u5206\u809d\u5207\u9664\uff08PHx\uff09\u5f8c\u8868\u73fe\u51fa\u56b4\u91cd\u7684\u518d\u751f\u7f3a\u9677\u3002\u7c92\u7dda\u9ad4 NAD+ \u4e0d\u8db3\u76f4\u63a5\u640d\u5bb3\u7c92\u7dda\u9ad4\u547c\u5438\u93c8\u8907\u5408\u7269 I \u7684\u529f\u80fd\uff0c\u964d\u4f4e\u8102\u80aa\u9178\u6c27\u5316\u6548\u7387\uff0c\u5f15\u767c\u809d\u81df\u80fd\u91cf\u4ee3\u8b1d\u5d29\u6f70\u3002\u7531\u6b64\u5c0e\u81f4\u7684 ATP \u7522\u91cf\u4e0d\u8db3\u963b\u7919\u4e86\u809d\u7d30\u80de\u589e\u6b96\uff0c\u9020\u6210\u809d\u81df\u91cd\u91cf\u6062\u5fa9\u5ef6\u9072\u548c\u518d\u751f\u671f\u9593\u5927\u91cf\u4e09\u9178\u7518\u6cb9\u8102\u5806\u7a4d\u3002\u9019\u5145\u5206\u8b49\u660e\uff0c\u7c92\u7dda\u9ad4 NAD+ \u7f3a\u4e4f\u662f\u5236\u7d04\u809d\u81df\u7d44\u7e54\u4fee\u5fa9\u7684\u6838\u5fc3\u74f6\u9838\u3002   <\/p>\n\n<h4 class=\"wp-block-heading\">3.2 \u7c92\u7dda\u9ad4 NAD+ \u5347\u9ad8\u986f\u8457\u52a0\u901f\u518d\u751f<\/h4>\n\n<p class=\"wp-block-paragraph\">AAV \u75c5\u6bd2\u4ecb\u5c0e\u7684\u809d\u7d30\u80de\u7279\u7570\u6027 SLC25A51 \u904e\u8868\u9054\u6709\u6548\u64f4\u5927\u4e86\u7c92\u7dda\u9ad4 NAD+ \u5132\u5eab\uff0c\u5e36\u4f86\u809d\u81df\u518d\u751f\u6307\u6a19\u7684\u5168\u9762\u6539\u5584\u3002\u5347\u9ad8\u7684\u7c92\u7dda\u9ad4 NAD+ \u6c34\u5e73\u6fc0\u6d3b\u4e86 PPAR \u8102\u8cea\u4ee3\u8b1d\u4fe1\u865f\u901a\u8def\uff0c\u4e0a\u8abf\u8102\u80aa\u9178\u5408\u6210\u548c\u5206\u89e3\u76f8\u95dc\u57fa\u56e0\uff0c\u6e1b\u5c11\u4fee\u5fa9\u904e\u7a0b\u4e2d\u7684\u7570\u5e38\u8102\u8cea\u5806\u7a4d\uff0c\u7dad\u6301\u7d30\u80de\u5167\u8102\u8cea\u7a69\u614b\u7a69\u5b9a\u3002\u8207\u6b64\u540c\u6642\uff0c\u589e\u5f37\u4e86\u7684\u7c92\u7dda\u9ad4\u80fd\u91cf\u4ee3\u8b1d\u63d0\u9ad8\u4e86\u809d\u81df ATP \u548c\u6838\u82f7\u4e09\u78f7\u9178\u542b\u91cf\uff0c\u7dad\u6301\u9ad8\u7d30\u80de\u80fd\u91cf\u8377\uff0c\u986f\u8457\u63d0\u5347\u809d\u7d30\u80de\u6709\u7d72\u5206\u88c2\u6307\u6578\u548c Ki-67 \u967d\u6027\u7d30\u80de\u6bd4\u4f8b\uff0c\u5927\u5e45\u7e2e\u77ed\u809d\u81df\u6062\u5fa9\u9031\u671f\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u7e3d\u800c\u8a00\u4e4b\uff0c\u7c92\u7dda\u9ad4 NAD+ \u809d\u81df\u518d\u751f\u4f9d\u8cf4\u5169\u689d\u76f8\u4e92\u652f\u6490\u7684\u6838\u5fc3\u901a\u8def\uff1a\u70ba\u7d30\u80de\u589e\u6b96\u63d0\u4f9b\u5145\u8db3\u7684\u80fd\u91cf\u52d5\u529b\uff0c\u4ee5\u53ca\u512a\u5316\u8102\u8cea\u4ee3\u8b1d\u5e73\u8861\u4ee5\u907f\u514d\u8102\u80aa\u8b8a\u6027\u5c0e\u81f4\u7684\u4fee\u5fa9\u53d7\u963b\u3002<\/p>\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"692\" height=\"422\" src=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-15.png\" alt=\"\" class=\"wp-image-27252\" title=\"\" srcset=\"https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-15.png 692w, https:\/\/www.celfull.com\/wp-content\/uploads\/2026\/07\/image-15-300x183.png 300w\" sizes=\"(max-width: 692px) 100vw, 692px\" \/><\/figure>\n\n<h3 class=\"wp-block-heading\">4. \u7a81\u7834\u6027\u81e8\u5e8a\u8f49\u5316\u50f9\u503c\u8207\u672a\u4f86\u7814\u7a76\u524d\u666f<\/h3>\n\n<p class=\"wp-block-paragraph\">\u9019\u9805 2025 \u5e74 Nature Metabolism \u7814\u7a76\u586b\u88dc\u4e86\u4e9e\u7d30\u80de NAD+ \u809d\u81df\u8abf\u63a7\u7814\u7a76\u7684\u9577\u671f\u7a7a\u767d\uff0c\u70ba\u81e8\u5e8a\u809d\u75c5\u5e72\u9810\u548c NAD+ \u61c9\u7528\u512a\u5316\u63d0\u4f9b\u4e86\u591a\u9805\u5275\u65b0\u7a81\u7834\u3002<\/p>\n\n<h4 class=\"wp-block-heading\">4.1 \u809d\u75c5\u6cbb\u7642\u7684\u7cbe\u6e96\u65b0\u9776\u9ede<\/h4>\n\n<p class=\"wp-block-paragraph\">SLC25A51 \u4ecb\u5c0e\u7684\u7c92\u7dda\u9ad4 NAD+ \u8f49\u904b\u88ab\u5b9a\u7fa9\u70ba\u809d\u81df\u4fee\u5fa9\u7684\u6838\u5fc3\u8abf\u63a7\u901a\u8def\u3002\u9776\u5411\u6fc0\u6d3b SLC25A51 \u529f\u80fd\u53ef\u7279\u7570\u6027\u63d0\u5347\u7c92\u7dda\u9ad4 NAD+ \u6c34\u5e73\uff0c\u70ba\u809d\u640d\u50b7\u3001\u809d\u786c\u5316\u548c\u79fb\u690d\u5f8c\u809d\u81df\u7d44\u7e54\u4fee\u5fa9\u63d0\u4f9b\u65b0\u7684\u7cbe\u6e96\u6cbb\u7642\u7b56\u7565\uff0c\u6253\u7834\u50b3\u7d71\u76f2\u76ee\u88dc\u5145 NAD+ \u7684\u5c40\u9650\u3002 <\/p>\n\n<h4 class=\"wp-block-heading\">4.2 NAD+ \u524d\u9ad4\u61c9\u7528\u7684\u512a\u5316\u65b9\u5411<\/h4>\n\n<p class=\"wp-block-paragraph\">\u73fe\u6709 NAD+ \u88dc\u5145\u5291\u81e8\u5e8a\u6548\u679c\u53c3\u5dee\u4e0d\u9f4a\uff0c\u6e90\u65bc\u5176\u7121\u6cd5\u9ad8\u6548\u9776\u5411\u7c92\u7dda\u9ad4 NAD+ \u5132\u5eab\u3002\u9019\u9805\u7814\u7a76\u6307\u51fa\u4e86\u6e05\u6670\u7684\u512a\u5316\u65b9\u5411\uff1a\u958b\u767c\u7c92\u7dda\u9ad4\u9776\u5411\u7684 NAD+ \u905e\u9001\u7cfb\u7d71\uff0c\u7cbe\u6e96\u88dc\u5145\u7c92\u7dda\u9ad4 NAD+\uff0c\u6700\u5927\u5316\u809d\u81df\u518d\u751f\u6548\u7387\uff0c\u63d0\u5347 NAD+ \u5e72\u9810\u7684\u5be6\u969b\u81e8\u5e8a\u50f9\u503c\u3002 <\/p>\n\n<h4 class=\"wp-block-heading\">4.3 \u4ee3\u8b1d\u6027\u809d\u75c5\u7684\u65b0\u751f\u7269\u6a19\u8a18<\/h4>\n\n<p class=\"wp-block-paragraph\">\u7c92\u7dda\u9ad4 NAD+ \u4ee3\u8b1d\u7d0a\u4e82\u8207\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u3001\u809d\u7e96\u7dad\u5316\u4e43\u81f3\u809d\u764c\u7684\u767c\u751f\u548c\u9032\u5c55\u5bc6\u5207\u76f8\u95dc\u3002SLC25A51 \u8868\u9054\u6c34\u5e73\u548c\u7c92\u7dda\u9ad4 NAD+ \u5132\u5eab\u72c0\u614b\u6709\u671b\u6210\u70ba\u4ee3\u8b1d\u6027\u809d\u75c5\u7684\u65b0\u578b\u8a3a\u65b7\u751f\u7269\u6a19\u8a18\u548c\u6cbb\u7642\u9776\u9ede\uff0c\u652f\u6301\u65e9\u671f\u7be9\u67e5\u548c\u7cbe\u6e96\u5e72\u9810\u3002 <\/p>\n\n<h3 class=\"wp-block-heading\">5. \u7d50\u8ad6\uff1a\u91cd\u65b0\u5b9a\u7fa9 NAD+ \u5c0d\u809d\u81df\u5065\u5eb7\u7684\u7cbe\u6e96\u8abf\u63a7<\/h3>\n\n<p class=\"wp-block-paragraph\">\u9577\u671f\u4ee5\u4f86\uff0c\u516c\u773e\u548c\u5b78\u8853\u754c\u90fd\u805a\u7126\u65bc\u6574\u9ad4 NAD+ \u6c34\u5e73\uff0c\u800c\u5ffd\u7565\u4e86\u4e9e\u7d30\u80de\u5340\u9694\u7684\u529f\u80fd\u5dee\u7570\u3002\u9019\u9805 2025 \u5e74\u6b0a\u5a01\u7814\u7a76\u9996\u6b21\u95e1\u660e\uff0c\u7c92\u7dda\u9ad4 NAD+ \u809d\u81df\u518d\u751f\u662f\u809d\u81df\u7d44\u7e54\u4fee\u5fa9\u7684\u6c7a\u5b9a\u6027\u6838\u5fc3\uff0c\u78ba\u8a8d\u4e86 SLC25A51 \u8f49\u904b\u86cb\u767d\u7684\u7368\u4f54\u8abf\u63a7\u4f5c\u7528\uff0c\u4e26\u63ed\u793a\u4e86\u7c92\u7dda\u9ad4 NAD+ \u5728\u80fd\u91cf\u4ee3\u8b1d\u548c\u8102\u8cea\u7a69\u614b\u4e2d\u7684\u96d9\u91cd\u4fdd\u969c\u6a5f\u5236\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u9019\u9805\u7814\u7a76\u63a8\u52d5 NAD+ \u809d\u81df\u5065\u5eb7\u7814\u7a76\u5f9e\u300c\u6574\u9ad4\u88dc\u5145\u300d\u8d70\u5411\u300c\u4e9e\u7d30\u80de\u7cbe\u6e96\u8abf\u63a7\u300d\u3002\u96a8\u7740\u5c0d\u7c92\u7dda\u9ad4 NAD+ \u4ee3\u8b1d\u7db2\u7d61\u7684\u6df1\u5165\u63a2\u7d22\uff0c\u5b83\u5c07\u4fc3\u9032 NAD+ \u57fa\u790e\u7814\u7a76\u5411\u81e8\u5e8a\u7cbe\u6e96\u6cbb\u7642\u7684\u8f49\u5316\uff0c\u70ba\u5168\u7403\u809d\u75c5\u60a3\u8005\u5e36\u4f86\u66f4\u9ad8\u6548\u3001\u66f4\u5177\u9776\u5411\u6027\u7684\u5e72\u9810\u65b9\u6848\u3002 <\/p>\n\n<h3 class=\"wp-block-heading\">References<\/h3>\n\n<p class=\"wp-block-paragraph\">Mukherjee S, Vel\u00e1zquez Aponte RA, Perry CE, Lee WD, Janssen KA, Niere M, Adzika GK, Lu MJ, Chan HR, Zou X, Chen B, Bye N, Xiao T, Yook JS, Salik O, Frederick DW, Gaspar RB, Doan KV, Davis JG, Rabinowitz JD, Wallace DC, Snyder NW, Kajimura S, Cambronne XA, Ziegler M, Baur JA. Hepatocyte mitochondrial NAD+ content is limiting for liver regeneration. Nat Metab. 2025 Dec;7(12):2424-2437.   <\/p>\n","protected":false},"excerpt":{"rendered":"<p>NAD+ \u662f\u4e3b\u5c0e\u7d30\u80de\u6c27\u5316\u9084\u539f\u53cd\u61c9\u3001\u80fd\u91cf\u4ee3\u8b1d\u548c\u4fe1\u865f\u8f49\u5c0e\u7684\u4e0d\u53ef\u6216\u7f3a\u7684\u6838\u5fc3\u8f14\u9176\u3002\u5176\u4ee3\u8b1d\u5931\u8861\u8207\u591a\u7a2e\u6162\u6027\u75be\u75c5\u548c\u5668\u5b98\u529f\u80fd\u969c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29771,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"page_builder":"","footnotes":""},"categories":[95],"tags":[],"class_list":["post-29770","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-95"],"_links":{"self":[{"href":"https:\/\/www.celfull.com\/zh-hant\/wp-json\/wp\/v2\/posts\/29770","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.celfull.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.celfull.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.celfull.com\/zh-hant\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.celfull.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=29770"}],"version-history":[{"count":1,"href":"https:\/\/www.celfull.com\/zh-hant\/wp-json\/wp\/v2\/posts\/29770\/revisions"}],"predecessor-version":[{"id":29772,"href":"https:\/\/www.celfull.com\/zh-hant\/wp-json\/wp\/v2\/posts\/29770\/revisions\/29772"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.celfull.com\/zh-hant\/wp-json\/wp\/v2\/media\/29771"}],"wp:attachment":[{"href":"https:\/\/www.celfull.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=29770"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.celfull.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=29770"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.celfull.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=29770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}