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Celfavor® MNMH

Reduced Nicotinamide Mononucleotide

Core Product Advantages

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  • As the reduced form of NMN and a highly efficient precursor of NAD+, NMNH can directly increase cellular NAD+ and NADH levels, effectively activate mitochondria, repair DNA, exert anti-inflammatory and antioxidant effects, protect organs, and improve metabolism. This results in rapid anti-fatigue effects, biological age reversal and anti-aging benefits.
  • Celfavor® NMNH uses microsphere encapsulation technology to stabilize activity, solving the problems of easy degradation, gastric acid decomposition and poor absorption of NMNH, and is more efficient than NMN and NR in boosting NAD+ levels, with remarkable metabolic activation and anti-aging effects.

Limitations of Conventional NMNH

Core Product Advantages

✖

Unstable

Ordinary NMNH has highly unstable chemical properties and is easily oxidized and degraded by light, temperature, humidity, air contact and gastric acid, greatly limiting its wide application.

✓

High stability

Celfavor's patented microsphere technology significantly improves the stability of active ingredients, enabling storage for 36 months at room temperature in the dark without degradation in gastric acid.

✖

Extremely low bioavailability

Easily degraded during room-temperature storage and in the gastric acid environment, unable to reach the intestinal tract for absorption.

✓

High bioavailability

100% stable retention in the stomach, targeted intestinal release; sustained release in the intestine, greatly improving absorption efficiency.

✓

Stable compounding

Suitable for hard capsules, can be compounded with other ingredients

Basic Product Information

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Item Details
Appearance Light yellow microspheres
(color customizable upon request)
NADH content 10%
Dosage form Capsule
Recommended dosage 10–20 mg/day
(based on NMNH content)

Core Efficacies

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1
Efficiently Increase NAD+: As a new NAD+ precursor, it is significantly better than NMN in speed and effect of increasing intracellular NAD+ and NADH levels.
2
Improve Mitochondrial Function: Up-regulate the expression of mitochondrial transcription factor Tfam, restore the function of the electron transport chain, and enhance mitochondrial energy metabolism.
3
Enhance Anti-oxidation Ability: Up-regulate the mRNA expression of glutathione peroxidase and peroxidase, and strengthen the cellular anti-oxidation defense line.
4
Promote Cell Proliferation and Repair: Promote cells to enter the S phase from the G1 phase, enhance cell repair ability, and help tissue damage repair.

Experimental Data

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Excellent Stability Under Digestion in Simulated Gastric Acid with pH 2.0

Excellent Stability Under Accelerated Conditions (37℃, 75% Humidity)

Male C57BL/6 mice weighing 20 g were randomly assigned to four groups and administered intragastrically with normal saline, NMN, NMNH, and Celfavor NMNH at a dose of 250 mg/kg, respectively. Blood samples were collected from the lateral saphenous vein at 2, 4, and 20 hours after the first intragastric administration. Another intragastric dose was given 20 hours later. Four hours after the second administration, the mice were sacrificed under isoflurane anesthesia. Blood and renal tubular epithelial cells were collected and immediately snap-frozen in liquid nitrogen.

Efficiency of Celfavor® NMNH in Increasing NAD+

Improve mitochondrial function (up-regulate the expression of mitochondrial transcription factor Tfam)