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A new study from Dalian Medical University, published in Cell, provides the clearest evidence to date that SARM1 acts as a direct DNA-damage sensor. When activated by abnormal double-stranded DNA (dsDNA), SARM1 rapidly degrades intracellular NAD⁺, triggering a cascade that leads to energy collapse and cell death. While the research focuses on chemotherapy-induced neuropathy and […]

We know that the age-related impairment of angiogenesis — the generation of new blood vessels — in the brain likely has a critical role in the development of vascular cognitive impairment and dementia in the elderly. We also know that levels of the vital molecule nicotinamide adenine dinucleotide (NAD+) decline with age in tissues and

Penn Medicine researchers have solved a decades old mystery around a key molecule fueling the power plant of cells that could be exploited to find new ways to treat diseases, from neurodegenerative disorders to cancer. Reporting in a new study published today in Nature, researchers from the Department of Physiology in the Perelman School of

No studies have found nicotinamide mononucleotide (NMN) consumption leads to side effects of insomnia. Yet, if you are new to the marketed dietary supplement, you might’ve seen bits on Reddit or other social media sites with individuals highlighting their newfound inability to sleep after taking NMN. Is there a connection between NMN supplements and trouble