Cell Study Identifies SARM1 as a DNA-Damage Sensor Driving NAD⁺ Depletion — A Mechanism with Implications for Aging and Cellular Resilience
A new study from Dalian Medical University, published in Cell, provides the clearest evidence to date that SARM1 acts as a direct DNA-damage sensor. When activated by abnormal double-stranded DNA (dsDNA), SARM1 rapidly degrades intracellular NAD⁺, triggering a cascade that leads to energy collapse and cell death. While the research focuses on chemotherapy-induced neuropathy and […]